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• W2074057570 abstract "In RNA fitness landscapes with interconnected networks of neutral mutations, neutral precursor mutations can play an important role in facilitating the accessibility of epistatic adaptive mutant combinations. I use an exhaustively surveyed fitness landscape model based on short sequence RNA genotypes (and their secondary structure phenotypes) to calculate the minimum rate at which mutants initially appearing as neutral are incorporated into an adaptive evolutionary walk. I show first, that incorporating neutral mutations significantly increases the number of point mutations in a given evolutionary walk when compared to estimates from previous adaptive walk models. Second, that incorporating neutral mutants into such a walk significantly increases the final fitness encountered on that walk - indeed evolutionary walks including neutral steps often reach the global optimum in this model. Third, and perhaps most importantly, evolutionary paths of this kind are often extremely winding in their nature and have the potential to undergo multiple mutations at a given sequence position within a single walk; the potential of these winding paths to mislead phylogenetic reconstruction is briefly considered." @default.
• W2074057570 created "2016-06-24" @default.
• W2074057570 creator A5049894575 @default.
• W2074057570 date "2011-02-01" @default.
• W2074057570 modified "2023-09-25" @default.
• W2074057570 title "Adaptive evolutionary walks require neutral intermediates in RNA fitness landscapes" @default.
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• W2074057570 doi "https://doi.org/10.1016/j.tpb.2010.10.001" @default.
• W2074057570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20937293" @default.
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