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- W2074059863 abstract "The goal of this study was to optimize key processes in recreating functional and viable palatal mucosa-like tissue that would be easy to handle and would promote wound healing. Normal human gingival fibroblasts and epithelial cells and a clinically useful biomaterial, CollaTape, were used. Structural and ultrastructural analyses showed that the gingival fibroblasts and epithelial cells adhered to the biomaterial and proliferated. Following a 6-day culture, using 10(5) fibroblasts and 10(6) epithelial cells, a well-organized palatal mucosa-like tissue was engineered. The engineered epithelium displayed various layers, including a stratum corneum, and contained cytokeratin 16-positive cells located in the supra-basal layer. This palatal mucosa-like engineered tissue was designed to meet a variety of surgical needs. The biodegradable collagen membrane (CollaTape) contributed to the flexibility of the engineered tissue. This engineered innovative tissue may contribute to the reconstruction of oral soft-tissue defects secondary to trauma, congenital defects, and acquired diseases." @default.
- W2074059863 created "2016-06-24" @default.
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- W2074059863 date "2007-04-26" @default.
- W2074059863 modified "2023-10-10" @default.
- W2074059863 title "Development of an engineering autologous palatal mucosa-like tissue for potential clinical applications" @default.
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- W2074059863 doi "https://doi.org/10.1002/jbm.b.30828" @default.
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