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- W207406276 abstract "Asthma is a chronic inflammatory condition characterized by bronchial hyper-responsiveness and reversible airway obstruction. A number of mediators have been implicated in the pathophysiology of this complex disease, including leukotrienes (LTs) (Ford-Hutchinson, 1989; Chanarin and Johnston, 1994). The biological effects of these arachidonic acid (AA) metabolites, including smooth muscle contraction, vasoconstriction and vascular permeability mimic the pathological changes seen in asthma (Ford-Hutchinson et al., 1980; Samuelsson, 1983; Jones et al., 1989). Furthermore, baseline LT production is higher in asthmatic subjects and is increased significantly during asthmatic attacks (Isono et al., 1985; Lam et al., 1988; Tagari et al., 1990; Knapp et al., 1992; Picado et al., 1992). The pro-inflammatory effects of LTs have also implicated these compounds in inflammatory bowel disease (IBD) (Rask-Madsen et al., 1992). The demonstration that LTs have properties associated with asthma and IBD has stimulated the development of many potential therapeutic agents to block the effects of these compounds." @default.
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- W207406276 date "1995-01-01" @default.
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- W207406276 title "Development of MK 0591: An Orally Active Leukotriene Biosynthesis Inhibitor with a Novel Mechanism of Action" @default.
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- W207406276 doi "https://doi.org/10.1007/978-1-4615-9846-6_8" @default.
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