FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074063640> ?p ?o ?g. }

• W2074063640 endingPage "765" @default.
• W2074063640 startingPage "758" @default.
• W2074063640 abstract "A recent report suggested that BQ (BQ) chewing significantly correlated with the occurrence of esophageal squamous cell carcinoma (ESCC) in Taiwanese. BQ chewing was shown to be associated with p53 mutation in oral cancers. However, the relationship between BQ chewing and p53 mutation in ESCC is unclear. Seventy-five primary ESCC patients were enrolled for mutational analysis of the p53 gene using polymerase chain amplification and direct sequencing of amplified product. Thirty-seven mutations of the p53 gene were detected in 45.5% (34/75) of tumor specimens. These mutations significantly clustered in exon 5 (21/37) of the p53 gene. The incidence of p53 mutations did not associate with clinicopathological characteristics or the habits of cigarette smoking or alcohol consumption. However, BQ chewers exhibited significantly higher incidence of p53 gene mutations than non-chewers (67.6% vs 32.4%, P = 0.007). After controlling the confounding factors of cigarette smoking and alcohol intake, BQ chewing still showed significant association with the incidence of p53 mutation in ESCCs (RR = 4.23; 95% CI, 1.317-13.60). The A:T to G:C transition (8/37, 21.6%) and G:C to T:A transversion (5/23, 13.5%) were the prevalent spectrum of p53 gene mutations. All A:T to G:C transitional mutations occurred in patients with the habits of BQ chewing and cigarette smoking. Noticeably, alcohol consumption could enhance this peculiar spectrum of p53 mutation in ESCC. Accordingly, p53 might be an important molecular target of BQ carcinogens in the development of ESCC in Taiwanese." @default.
• W2074063640 created "2016-06-24" @default.
• W2074063640 creator A5008496601 @default.
• W2074063640 creator A5022990549 @default.
• W2074063640 creator A5034188787 @default.
• W2074063640 creator A5039089534 @default.
• W2074063640 creator A5049167405 @default.
• W2074063640 date "2005-11-01" @default.
• W2074063640 modified "2023-10-15" @default.
• W2074063640 title "Risk of p53 gene mutation in esophageal squamous cell carcinoma and habit of betel quid chewing in Taiwanese" @default.
• W2074063640 cites W1540778682 @default.
• W2074063640 cites W1963600744 @default.
• W2074063640 cites W1965815004 @default.
• W2074063640 cites W1973223683 @default.
• W2074063640 cites W1975989949 @default.
• W2074063640 cites W1987466914 @default.
• W2074063640 cites W1991494214 @default.
• W2074063640 cites W1993888508 @default.
• W2074063640 cites W2000605829 @default.
• W2074063640 cites W2005701686 @default.
• W2074063640 cites W2012053348 @default.
• W2074063640 cites W2021481730 @default.
• W2074063640 cites W2022106386 @default.
• W2074063640 cites W2026597923 @default.
• W2074063640 cites W2042316019 @default.
• W2074063640 cites W2054549064 @default.
• W2074063640 cites W2054768526 @default.
• W2074063640 cites W2056008056 @default.
• W2074063640 cites W2065081049 @default.
• W2074063640 cites W2065940125 @default.
• W2074063640 cites W2071182076 @default.
• W2074063640 cites W2073576377 @default.
• W2074063640 cites W2077641692 @default.
• W2074063640 cites W2086368369 @default.
• W2074063640 cites W2087031979 @default.
• W2074063640 cites W2088344791 @default.
• W2074063640 cites W2089220441 @default.
• W2074063640 cites W2102578583 @default.
• W2074063640 cites W2120357219 @default.
• W2074063640 cites W2156004684 @default.
• W2074063640 cites W2165449818 @default.
• W2074063640 cites W2169274488 @default.
• W2074063640 cites W2171729019 @default.
• W2074063640 cites W2312732552 @default.
• W2074063640 cites W4252871087 @default.
• W2074063640 cites W57948405 @default.
• W2074063640 doi "https://doi.org/10.1111/j.1349-7006.2005.00115.x" @default.
• W2074063640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16271069" @default.
• W2074063640 hasPublicationYear "2005" @default.
• W2074063640 type Work @default.
• W2074063640 sameAs 2074063640 @default.
• W2074063640 citedByCount "27" @default.
• W2074063640 countsByYear W20740636402012 @default.
• W2074063640 countsByYear W20740636402013 @default.
• W2074063640 countsByYear W20740636402014 @default.
• W2074063640 countsByYear W20740636402015 @default.
• W2074063640 countsByYear W20740636402016 @default.
• W2074063640 countsByYear W20740636402017 @default.
• W2074063640 countsByYear W20740636402019 @default.
• W2074063640 countsByYear W20740636402020 @default.
• W2074063640 countsByYear W20740636402021 @default.
• W2074063640 countsByYear W20740636402022 @default.
• W2074063640 crossrefType "journal-article" @default.
• W2074063640 hasAuthorship W2074063640A5008496601 @default.
• W2074063640 hasAuthorship W2074063640A5022990549 @default.
• W2074063640 hasAuthorship W2074063640A5034188787 @default.
• W2074063640 hasAuthorship W2074063640A5039089534 @default.
• W2074063640 hasAuthorship W2074063640A5049167405 @default.
• W2074063640 hasBestOaLocation W20740636401 @default.
• W2074063640 hasConcept C104317684 @default.
• W2074063640 hasConcept C120665830 @default.
• W2074063640 hasConcept C121332964 @default.
• W2074063640 hasConcept C126322002 @default.
• W2074063640 hasConcept C127413603 @default.
• W2074063640 hasConcept C143998085 @default.
• W2074063640 hasConcept C206391251 @default.
• W2074063640 hasConcept C2777417228 @default.
• W2074063640 hasConcept C2777546739 @default.
• W2074063640 hasConcept C2779741799 @default.
• W2074063640 hasConcept C2994225774 @default.
• W2074063640 hasConcept C36823959 @default.
• W2074063640 hasConcept C49105822 @default.
• W2074063640 hasConcept C501734568 @default.
• W2074063640 hasConcept C502942594 @default.
• W2074063640 hasConcept C54355233 @default.
• W2074063640 hasConcept C61511704 @default.
• W2074063640 hasConcept C64872895 @default.
• W2074063640 hasConcept C66938386 @default.
• W2074063640 hasConcept C71924100 @default.
• W2074063640 hasConcept C86803240 @default.
• W2074063640 hasConcept C90924648 @default.
• W2074063640 hasConceptScore W2074063640C104317684 @default.
• W2074063640 hasConceptScore W2074063640C120665830 @default.
• W2074063640 hasConceptScore W2074063640C121332964 @default.
• W2074063640 hasConceptScore W2074063640C126322002 @default.
• W2074063640 hasConceptScore W2074063640C127413603 @default.
• W2074063640 hasConceptScore W2074063640C143998085 @default.
• W2074063640 hasConceptScore W2074063640C206391251 @default.

• next