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• W2074067362 abstract "ATP is an important cell-to-cell signaling molecule mediating the interactions between astrocytes and neurons in the CNS. In the hippocampal slices, ATP suppresses excitatory transmission mostly through activation of adenosine A 1 receptors, because the ectoenzyme activity for the extracellular breakdown of ATP to adenosine is high in slice preparations in contrast to culture environments. Because the hippocampus is also rich in the expression of P2 receptors activated specifically by ATP, we examined whether ATP modulates neuronal excitability in the acute slice preparations independently of adenosine receptors. Although ATP decreased the frequency of spontaneously occurring EPSCs in the CA3 pyramidal neurons through activation of adenosine A 1 receptors, ATP concurrently increased the frequency of IPSCs in a manner dependent on action potential generation. This effect was mediated by P2Y 1 receptors because (1) 2-methylthio-ATP (2meSATP) was the most potent agonist, (2) 2′-deoxy- N 6 -methyladenosine-3′,5′-bisphosphate diammonium (MRS2179) abolished this effect, and (3) this increase in IPSC frequency was not observed in the transgenic mice lacking P2Y 1 receptor proteins. Application of 2meSATP elicited MRS2179-sensitive time- and voltage-dependent inward currents in the interneurons, which depolarized the cell to firing threshold. Also, it increased [Ca 2+ ] i in both astrocytes and interneurons, but, unlike the former effect, the latter was entirely dependent on Ca 2+ entry. Thus, in hippocampal slices, in addition to activating A 1 receptors of the excitatory terminals after being converted to adenosine, ATP activates P2Y 1 receptors in the interneurons, which is linked to activation of unidentified excitatory conductance, through mechanisms distinct from those in the astrocytes." @default.
• W2074067362 created "2016-06-24" @default.
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• W2074067362 date "2004-12-01" @default.
• W2074067362 modified "2023-10-15" @default.
• W2074067362 title "Direct Excitation of Inhibitory Interneurons by Extracellular ATP Mediated by P2Y₁Receptors in the Hippocampal Slice" @default.
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• W2074067362 doi "https://doi.org/10.1523/jneurosci.3028-04.2004" @default.
• W2074067362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6730213" @default.
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