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- W2074069151 startingPage "535" @default.
- W2074069151 abstract "Place fields of hippocampal pyramidal cells expand asymmetrically when adult rats repeatedly follow the same route. This behaviorally induced expression of neuronal plasticity uses an NMDAR-dependent, LTP-like mechanism and could be used by hippocampal networks to store information. Aged spatial memory-impaired rats exhibit defective experience-dependent place field expansion plasticity. One possible explanation for this aged-associated deficit is alterations in glutamatergic function. In fact, both NMDAR- and AMPAR-mediated field excitatory postsynaptic potentials in CA1 decrease with aging. The current study investigated whether modulation of either AMPA or NDMA receptor activity could restore this experience-dependent plasticity by prolonging AMPAR activity with the ampakine CX516 and modulating the NMDAR with the noncompetitive antagonist memantine. The spatial firing characteristics of multiple CA1 pyramidal cells were monitored under both treatment conditions as aged rats repeatedly traversed a circular track. Compared to the saline baseline condition, acute administration of memantine, but not CX516, reinstated experience-dependent place field expansion. Taken together, these data suggest that pharmacological manipulation of the NMDAR can improve the function of hippocampal networks critical to optimal cognition in aging." @default.
- W2074069151 created "2016-06-24" @default.
- W2074069151 creator A5010597355 @default.
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- W2074069151 creator A5036008088 @default.
- W2074069151 creator A5042422785 @default.
- W2074069151 creator A5082026369 @default.
- W2074069151 date "2008-01-01" @default.
- W2074069151 modified "2023-10-14" @default.
- W2074069151 title "Glutamate receptor-mediated restoration of experience-dependent place field expansion plasticity in aged rats." @default.
- W2074069151 cites W1506209295 @default.
- W2074069151 cites W1545157894 @default.
- W2074069151 cites W1568903867 @default.
- W2074069151 cites W1585564530 @default.
- W2074069151 cites W1605489310 @default.
- W2074069151 cites W1630370318 @default.
- W2074069151 cites W1817525470 @default.
- W2074069151 cites W1966788003 @default.
- W2074069151 cites W1967480902 @default.
- W2074069151 cites W1969769253 @default.
- W2074069151 cites W1973311433 @default.
- W2074069151 cites W1973372728 @default.
- W2074069151 cites W1974719406 @default.
- W2074069151 cites W1977901685 @default.
- W2074069151 cites W1981117745 @default.
- W2074069151 cites W1986503634 @default.
- W2074069151 cites W1988407393 @default.
- W2074069151 cites W1992388076 @default.
- W2074069151 cites W1996239128 @default.
- W2074069151 cites W1998955447 @default.
- W2074069151 cites W2001189179 @default.
- W2074069151 cites W2004725045 @default.
- W2074069151 cites W2004974848 @default.
- W2074069151 cites W2005016731 @default.
- W2074069151 cites W2006099430 @default.
- W2074069151 cites W2007265755 @default.
- W2074069151 cites W2011035664 @default.
- W2074069151 cites W2011670890 @default.
- W2074069151 cites W2016106846 @default.
- W2074069151 cites W2016332821 @default.
- W2074069151 cites W2017169966 @default.
- W2074069151 cites W2020789218 @default.
- W2074069151 cites W2027438525 @default.
- W2074069151 cites W2027699509 @default.
- W2074069151 cites W2029717323 @default.
- W2074069151 cites W2031843068 @default.
- W2074069151 cites W2032673357 @default.
- W2074069151 cites W2033797595 @default.
- W2074069151 cites W2037811130 @default.
- W2074069151 cites W2038223805 @default.
- W2074069151 cites W2038492152 @default.
- W2074069151 cites W2041592862 @default.
- W2074069151 cites W2042261461 @default.
- W2074069151 cites W2043109020 @default.
- W2074069151 cites W2050490622 @default.
- W2074069151 cites W2052151896 @default.
- W2074069151 cites W2052515926 @default.
- W2074069151 cites W2052884971 @default.
- W2074069151 cites W2063067007 @default.
- W2074069151 cites W2063103417 @default.
- W2074069151 cites W2069776467 @default.
- W2074069151 cites W2071668347 @default.
- W2074069151 cites W2075173841 @default.
- W2074069151 cites W2084367597 @default.
- W2074069151 cites W2087728854 @default.
- W2074069151 cites W2091362970 @default.
- W2074069151 cites W2091697313 @default.
- W2074069151 cites W2092458637 @default.
- W2074069151 cites W2092884162 @default.
- W2074069151 cites W2093651696 @default.
- W2074069151 cites W2097075649 @default.
- W2074069151 cites W2102973376 @default.
- W2074069151 cites W2103861118 @default.
- W2074069151 cites W2103993985 @default.
- W2074069151 cites W2110724392 @default.
- W2074069151 cites W2113273079 @default.
- W2074069151 cites W2114163624 @default.
- W2074069151 cites W2115348689 @default.
- W2074069151 cites W2119565218 @default.
- W2074069151 cites W2128216497 @default.
- W2074069151 cites W2133958927 @default.
- W2074069151 cites W2151425581 @default.
- W2074069151 cites W2157231154 @default.
- W2074069151 cites W2161260984 @default.
- W2074069151 cites W2162720865 @default.
- W2074069151 cites W2163186438 @default.
- W2074069151 cites W2163401269 @default.
- W2074069151 cites W2164518646 @default.
- W2074069151 cites W2164700170 @default.
- W2074069151 cites W2169473035 @default.
- W2074069151 cites W2169728516 @default.
- W2074069151 cites W2171826208 @default.
- W2074069151 cites W2303708813 @default.
- W2074069151 cites W2416581617 @default.
- W2074069151 cites W2605970404 @default.
- W2074069151 doi "https://doi.org/10.1037/0735-7044.122.3.535" @default.
- W2074069151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2773228" @default.
- W2074069151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18513124" @default.