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- W2074071910 abstract "This study was carried out to investigate whether the pulmonary C-fiber hypersensitivity induced by hyperthermia is altered by prostaglandin E 2 (PGE 2 ). Single-unit afferent activities of pulmonary C-fibers were recorded in anesthetized, artificially ventilated rats when the intrathoracic temperature ( T it ) was maintained at normal (N; ∼36 °C) and hyperthermia levels (H; ∼41 °C) by perfusion of heated saline into the thoracic chamber for 3 min. After ∼20 min of recovery, the fiber activities were recorded again during infusion of PGE 2 at both N and H levels of T it . Our study showed: (1) The baseline fiber activity and responses to lung inflation, right-atrial injection of capsaicin and adenosine were all increased by increasing T it from N to H, and these hyperthermia-induced increases in sensitivities were also significantly augmented by PGE 2 . (2) These enhanced sensitivities induced by PGE 2 were abolished by pretreatment with AH6809 and AH23848, selective antagonists of EP 2 and EP 4 prostanoid receptors, respectively. In conclusion, the hyperthermia-induced hypersensitivity of vagal pulmonary C-fibers is potentiated by PGE 2 , and this effect is mediated through activation of EP 2 and EP 4 prostanoid receptors." @default.
- W2074071910 created "2016-06-24" @default.
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- W2074071910 date "2007-06-01" @default.
- W2074071910 modified "2023-10-18" @default.
- W2074071910 title "Prostaglandin E2 enhances the sensitizing effect of hyperthermia on pulmonary C-fibers in rats" @default.
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- W2074071910 doi "https://doi.org/10.1016/j.resp.2006.11.003" @default.
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