Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074076965> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2074076965 endingPage "130" @default.
- W2074076965 startingPage "124" @default.
- W2074076965 abstract "T-brain-1 (Tbr-1), a brain-specific T-box transcription factor, plays a critical role in cerebral cortex and olfactory bulb development. The expression levels of Tbr-1 are highest at the embryonic stage and are gradually reduced during the developmental process. In adult brain, Tbr-1 is expressed at a lower, but still significant level. Tbr-1 transcriptional activity is enhanced via interaction with CASK, a membrane-associated guanylate kinase, but it is not clear whether any other mechanism regulates Tbr-1 activity. We examined the subcellular distribution of Tbr-1 in adult and postnatal rat brains using DAB stain and confocal imaging analysis. In contrast to the embryonic stage, Tbr-1 was distributed in P3 and adult rat brain in the nucleus as well as the cytoplasm of neurons in the cerebral cortex and hippocampus. Confocal analysis clearly showed dendritic distribution of Tbr-1 in pyramidal neurons. In the cerebellum of P15, P22, and adult rats, Tbr-1 was specifically expressed in Purkinje cells, where Tbr-1 was localised in the cytoplasm, including the dendritic tree. In addition, biochemical fractionation of adult cerebral cortex and hippocampus showed that cytoplasmic Tbr-1 is highly enriched in the lysed synaptosomal fraction, further indicating a synaptic distribution of cytoplasmic Tbr-1 in adult brain. Our study suggests that translocation from synapse to the nucleus is involved in regulation of Tbr-1 function in postnatal and adult brains." @default.
- W2074076965 created "2016-06-24" @default.
- W2074076965 creator A5038813737 @default.
- W2074076965 creator A5055749746 @default.
- W2074076965 date "2007-05-01" @default.
- W2074076965 modified "2023-09-23" @default.
- W2074076965 title "Cytoplasmic distribution of T-box transcription factor Tbr-1 in adult rodent brain" @default.
- W2074076965 cites W1624747402 @default.
- W2074076965 cites W1898303357 @default.
- W2074076965 cites W1918894800 @default.
- W2074076965 cites W1919311176 @default.
- W2074076965 cites W1970748319 @default.
- W2074076965 cites W1974374273 @default.
- W2074076965 cites W1977677498 @default.
- W2074076965 cites W1990500865 @default.
- W2074076965 cites W1990935914 @default.
- W2074076965 cites W2014336176 @default.
- W2074076965 cites W2026840085 @default.
- W2074076965 cites W2029245198 @default.
- W2074076965 cites W2039463257 @default.
- W2074076965 cites W2076636373 @default.
- W2074076965 cites W2077576116 @default.
- W2074076965 cites W2082301167 @default.
- W2074076965 cites W2091738825 @default.
- W2074076965 cites W2121132840 @default.
- W2074076965 cites W2124478777 @default.
- W2074076965 cites W2148670691 @default.
- W2074076965 cites W2164174276 @default.
- W2074076965 cites W2260148427 @default.
- W2074076965 cites W2300202108 @default.
- W2074076965 cites W4248951783 @default.
- W2074076965 doi "https://doi.org/10.1016/j.jchemneu.2007.01.005" @default.
- W2074076965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17329080" @default.
- W2074076965 hasPublicationYear "2007" @default.
- W2074076965 type Work @default.
- W2074076965 sameAs 2074076965 @default.
- W2074076965 citedByCount "15" @default.
- W2074076965 countsByYear W20740769652012 @default.
- W2074076965 countsByYear W20740769652014 @default.
- W2074076965 countsByYear W20740769652015 @default.
- W2074076965 countsByYear W20740769652017 @default.
- W2074076965 countsByYear W20740769652020 @default.
- W2074076965 countsByYear W20740769652023 @default.
- W2074076965 crossrefType "journal-article" @default.
- W2074076965 hasAuthorship W2074076965A5038813737 @default.
- W2074076965 hasAuthorship W2074076965A5055749746 @default.
- W2074076965 hasConcept C104317684 @default.
- W2074076965 hasConcept C169760540 @default.
- W2074076965 hasConcept C190062978 @default.
- W2074076965 hasConcept C2777348757 @default.
- W2074076965 hasConcept C2779652256 @default.
- W2074076965 hasConcept C2780496858 @default.
- W2074076965 hasConcept C2780723820 @default.
- W2074076965 hasConcept C2781041448 @default.
- W2074076965 hasConcept C2781161787 @default.
- W2074076965 hasConcept C529278444 @default.
- W2074076965 hasConcept C55493867 @default.
- W2074076965 hasConcept C86339819 @default.
- W2074076965 hasConcept C86803240 @default.
- W2074076965 hasConcept C95444343 @default.
- W2074076965 hasConceptScore W2074076965C104317684 @default.
- W2074076965 hasConceptScore W2074076965C169760540 @default.
- W2074076965 hasConceptScore W2074076965C190062978 @default.
- W2074076965 hasConceptScore W2074076965C2777348757 @default.
- W2074076965 hasConceptScore W2074076965C2779652256 @default.
- W2074076965 hasConceptScore W2074076965C2780496858 @default.
- W2074076965 hasConceptScore W2074076965C2780723820 @default.
- W2074076965 hasConceptScore W2074076965C2781041448 @default.
- W2074076965 hasConceptScore W2074076965C2781161787 @default.
- W2074076965 hasConceptScore W2074076965C529278444 @default.
- W2074076965 hasConceptScore W2074076965C55493867 @default.
- W2074076965 hasConceptScore W2074076965C86339819 @default.
- W2074076965 hasConceptScore W2074076965C86803240 @default.
- W2074076965 hasConceptScore W2074076965C95444343 @default.
- W2074076965 hasIssue "3" @default.
- W2074076965 hasLocation W20740769651 @default.
- W2074076965 hasLocation W20740769652 @default.
- W2074076965 hasOpenAccess W2074076965 @default.
- W2074076965 hasPrimaryLocation W20740769651 @default.
- W2074076965 hasRelatedWork W1769986759 @default.
- W2074076965 hasRelatedWork W1991099788 @default.
- W2074076965 hasRelatedWork W2027456808 @default.
- W2074076965 hasRelatedWork W2063883903 @default.
- W2074076965 hasRelatedWork W2124031048 @default.
- W2074076965 hasRelatedWork W2129867886 @default.
- W2074076965 hasRelatedWork W2167022370 @default.
- W2074076965 hasRelatedWork W2360612347 @default.
- W2074076965 hasRelatedWork W2419192173 @default.
- W2074076965 hasRelatedWork W2785171048 @default.
- W2074076965 hasVolume "33" @default.
- W2074076965 isParatext "false" @default.
- W2074076965 isRetracted "false" @default.
- W2074076965 magId "2074076965" @default.
- W2074076965 workType "article" @default.