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- W2074077423 abstract "Glycogen synthesis was studied in rat hepatocytes isolated by EDTA perfusion. Insulin induced a one and a half to twofold increase in glucose incorporation into glycogen. Insulin stimulated glycogen synthesis was inhibited by the phosphatidylinositol 3-kinase inhibitors wortmannin (IC50 approximately 40 nM) and LY 294002 (IC50 approximately 20 microM) and the mitogen-activated protein kinase kinase inhibitor PD 98059 (IC50 approximately 40 microM). Wortmannin was without appreciable effect on non-insulin stimulated glycogen synthesis, while LY 294002 and PD 98059 also inhibited the non-insulin stimulated glycogen synthesis. Rapamycin, an inhibitor of p70 ribosomal protein-S6 kinase, was without effect on glycogen synthesis regardless of insulin stimulation." @default.
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- W2074077423 date "1997-09-01" @default.
- W2074077423 modified "2023-10-16" @default.
- W2074077423 title "Insulin Stimulated Glycogen Synthesis in Isolated Rat Hepatocytes: Effect of Protein Kinase Inhibitors" @default.
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- W2074077423 doi "https://doi.org/10.1016/s0898-6568(97)00035-1" @default.
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