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- W2074080214 abstract "Abstract Enalapril maleate contains alanylproline dipeptide and can be split into two or more peaks when separated by reversed-phase liquid chromatography. The dependence of the shape, retention or width of peaks of enalapril and its impurities on temperature, pH, ionic strength and presence of ion-pairing compounds was studied. The optimum separation conditions involve a state where the rotational rates are much higher than that of the separation process, i.e., at a higher temperature and lower pH. Enalapril is eluted as a single peak even at room temperature at higher concentrations of both cetyltrimethylammonium bromide and sodium dodecyl sulphate in the mobile phase." @default.
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- W2074080214 date "1991-01-01" @default.
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- W2074080214 title "Elimination of peak splitting in the liquid chromatography of the proline-containing drug enalapril maleate" @default.
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- W2074080214 doi "https://doi.org/10.1016/s0021-9673(01)88898-1" @default.
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