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- W2074080380 abstract "In HeLa cells, synthesis of all high molecular weight RNA is reversibly inhibited in the presence of 5 μm-camptothecin, which has no detectable effect on protein synthesis for about three hours. While previously synthesized 45 S ribosomal precursor RNA (pre-rRNA) undergoes normal processing in the presence of the inhibitor, the 50 S ribosomal subunits containing 28 S rRNA accumulate in the nucleoplasm. On removal of the inhibitor 45 S pre-rRNA synthesis resumes, and the accumulated nucleoplasmic 28 S rRNA is rapidly transferred to the cytoplasm. This transport of newly formed 28 S rRNA from nucleus to the cytoplasm is blocked when ribosomal RNA synthesis is selectively inhibited by a low dose of actinomycin D. The results imply that concurrent transcription of 45 S pre-rRNA is essential for the continuance of later stages of ribosomal processing." @default.
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- W2074080380 date "1973-10-01" @default.
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- W2074080380 title "Role of ribosomal RNA transcription in ribosome processing in HeLa cells" @default.
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- W2074080380 doi "https://doi.org/10.1016/0022-2836(73)90172-1" @default.
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