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- W2074082893 abstract "A method is described allowing the identification and separation of the sulphate esters of the glycol metabolites of [14C]noradrenaline injected into the lateral ventricle of the rat. The esters of both the 3,4-dihydroxy derivative and the 3-methoxy-4-hydroxy derivative are formed in substantial amounts. It is suggested that the quantity of the former may have been underestimated in the past. Contemporaneous administration of pyrogallol, a catechol-O-methyl transferase inhibitor, with [14C] noradrenaline leads to a considerable fall in 3-methoxy-4-hydroxyphenylglycol sulphate without a rise in 3-4-dihydroxyphenylglycol sulphate although free 3-4-dihydroxyphenylglycol rises significantly. It is proposed that the latter may be an index of intraneuronal metabolism of noradrenaline and 3-methoxy-4-hydroxyphenylglycol that of released amine." @default.
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- W2074082893 date "1971-12-01" @default.
- W2074082893 modified "2023-10-14" @default.
- W2074082893 title "GLYCOL SULPHATE ESTER FORMATION FROM [14C]NORADRENALINE IN BRAIN AND THE INFLUENCE OF A COMT INHIBITOR" @default.
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- W2074082893 doi "https://doi.org/10.1111/j.1471-4159.1971.tb00203.x" @default.
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