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- W2074085078 abstract "Amphotericin B is an effective but toxic antileishmanial agent. Lipid-encapsulated amphotericin B should have a high therapeutic index for visceral leishmaniasis because reticuloendothelial cells, the sole site in which Leishmania is found, will phagocytize and concentrate the complex. Amphotericin B cholesterol dispersion (Amphocil; 2 mg/[kg · d] intravenously) was administered to 10 Brazilians with kala-azar for 10 days (cohort 1) and to 10 Brazilians with kala-azar for 7 days (cohort 2). All patients were successfully treated: 19 of the 20 patients were without visible parasites in the bone marrow; the mean time to afebrility was 4.2 days; spleen size regressed by a mean of 79% 2 months after therapy; and no patient had clinical or laboratory abnormalities by the end of 6–12 months of follow-up. Side effects were fever and chills accompanied by respiratory distress, but not nephrotoxicity, in children <3 years of age." @default.
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- W2074085078 date "1993-12-01" @default.
- W2074085078 modified "2023-10-06" @default.
- W2074085078 title "Treatment of Brazilian Kala-Azar with a Short Course of Amphocil (Amphotericin B Cholesterol Dispersion)" @default.
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- W2074085078 doi "https://doi.org/10.1093/clinids/17.6.981" @default.
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