Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074088319> ?p ?o ?g. }
- W2074088319 endingPage "5332" @default.
- W2074088319 startingPage "5324" @default.
- W2074088319 abstract "Diamidines 10a−g and 18a,b were obtained from dinitriles 9a−g and 15a,b by treatment with lithium trimethylsilylamide or upon hydrogenation of bis-O-acetoxyamidoximes. Dinitriles 9a−g were prepared via Suzuki reactions between arylboronic acids and arylnitriles. Potential prodrugs 12a−f and 17 were prepared via methylation of the diamidoximes 11a−f and 16a. Significant DNA affinities for rigid-rod molecules were observed. Compounds 10a, 10b, 10d, 18a, and 18b show IC50 values of 5 nM or less against Trypanosoma brucei rhodesiense (T. b. r.) and 10a, 10b, 10e, 18a, and 18b gave similar ones against Plasmodium falciparum (P.f.). The dications, 10a, 10d, 10f, and 10g are more active than furamidine in vivo. The prodrugs are only moderately effective on oral administration. Mouse liver microsome bioconversion of the methamidoxime prodrugs is significantly reduced from that of pafuramidine and suggests that the in vivo efficacy of these prodrugs is, in part, due to poor bioconversion." @default.
- W2074088319 created "2016-06-24" @default.
- W2074088319 creator A5013955348 @default.
- W2074088319 creator A5018556256 @default.
- W2074088319 creator A5019942523 @default.
- W2074088319 creator A5021453491 @default.
- W2074088319 creator A5027331158 @default.
- W2074088319 creator A5050874457 @default.
- W2074088319 creator A5051539758 @default.
- W2074088319 creator A5065623289 @default.
- W2074088319 creator A5076626346 @default.
- W2074088319 creator A5086616575 @default.
- W2074088319 date "2006-07-29" @default.
- W2074088319 modified "2023-09-25" @default.
- W2074088319 title "Synthesis, DNA Affinity, and Antiprotozoal Activity of Linear Dications: Terphenyl Diamidines and Analogues" @default.
- W2074088319 cites W1971015083 @default.
- W2074088319 cites W1972951380 @default.
- W2074088319 cites W1982341138 @default.
- W2074088319 cites W2008962877 @default.
- W2074088319 cites W2028311915 @default.
- W2074088319 cites W2035871329 @default.
- W2074088319 cites W2036987218 @default.
- W2074088319 cites W2045327264 @default.
- W2074088319 cites W2046021558 @default.
- W2074088319 cites W2054129231 @default.
- W2074088319 cites W2062444247 @default.
- W2074088319 cites W2070211116 @default.
- W2074088319 cites W2071894706 @default.
- W2074088319 cites W2082131361 @default.
- W2074088319 cites W2091590794 @default.
- W2074088319 cites W2102526494 @default.
- W2074088319 cites W2105845464 @default.
- W2074088319 cites W2112502447 @default.
- W2074088319 cites W2125141220 @default.
- W2074088319 cites W2126547274 @default.
- W2074088319 cites W2134012524 @default.
- W2074088319 cites W2949403327 @default.
- W2074088319 cites W4248362137 @default.
- W2074088319 doi "https://doi.org/10.1021/jm060470p" @default.
- W2074088319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16913722" @default.
- W2074088319 hasPublicationYear "2006" @default.
- W2074088319 type Work @default.
- W2074088319 sameAs 2074088319 @default.
- W2074088319 citedByCount "70" @default.
- W2074088319 countsByYear W20740883192012 @default.
- W2074088319 countsByYear W20740883192013 @default.
- W2074088319 countsByYear W20740883192014 @default.
- W2074088319 countsByYear W20740883192015 @default.
- W2074088319 countsByYear W20740883192016 @default.
- W2074088319 countsByYear W20740883192017 @default.
- W2074088319 countsByYear W20740883192018 @default.
- W2074088319 countsByYear W20740883192019 @default.
- W2074088319 countsByYear W20740883192020 @default.
- W2074088319 countsByYear W20740883192021 @default.
- W2074088319 countsByYear W20740883192022 @default.
- W2074088319 countsByYear W20740883192023 @default.
- W2074088319 crossrefType "journal-article" @default.
- W2074088319 hasAuthorship W2074088319A5013955348 @default.
- W2074088319 hasAuthorship W2074088319A5018556256 @default.
- W2074088319 hasAuthorship W2074088319A5019942523 @default.
- W2074088319 hasAuthorship W2074088319A5021453491 @default.
- W2074088319 hasAuthorship W2074088319A5027331158 @default.
- W2074088319 hasAuthorship W2074088319A5050874457 @default.
- W2074088319 hasAuthorship W2074088319A5051539758 @default.
- W2074088319 hasAuthorship W2074088319A5065623289 @default.
- W2074088319 hasAuthorship W2074088319A5076626346 @default.
- W2074088319 hasAuthorship W2074088319A5086616575 @default.
- W2074088319 hasConcept C100544194 @default.
- W2074088319 hasConcept C104317684 @default.
- W2074088319 hasConcept C108215921 @default.
- W2074088319 hasConcept C150903083 @default.
- W2074088319 hasConcept C185592680 @default.
- W2074088319 hasConcept C202751555 @default.
- W2074088319 hasConcept C207001950 @default.
- W2074088319 hasConcept C2776635100 @default.
- W2074088319 hasConcept C2779502636 @default.
- W2074088319 hasConcept C2780074830 @default.
- W2074088319 hasConcept C2909346784 @default.
- W2074088319 hasConcept C55493867 @default.
- W2074088319 hasConcept C71240020 @default.
- W2074088319 hasConcept C71924100 @default.
- W2074088319 hasConcept C86803240 @default.
- W2074088319 hasConcept C87644729 @default.
- W2074088319 hasConcept C98274493 @default.
- W2074088319 hasConceptScore W2074088319C100544194 @default.
- W2074088319 hasConceptScore W2074088319C104317684 @default.
- W2074088319 hasConceptScore W2074088319C108215921 @default.
- W2074088319 hasConceptScore W2074088319C150903083 @default.
- W2074088319 hasConceptScore W2074088319C185592680 @default.
- W2074088319 hasConceptScore W2074088319C202751555 @default.
- W2074088319 hasConceptScore W2074088319C207001950 @default.
- W2074088319 hasConceptScore W2074088319C2776635100 @default.
- W2074088319 hasConceptScore W2074088319C2779502636 @default.
- W2074088319 hasConceptScore W2074088319C2780074830 @default.
- W2074088319 hasConceptScore W2074088319C2909346784 @default.
- W2074088319 hasConceptScore W2074088319C55493867 @default.
- W2074088319 hasConceptScore W2074088319C71240020 @default.
- W2074088319 hasConceptScore W2074088319C71924100 @default.