FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074089690> ?p ?o ?g. }

• W2074089690 endingPage "448" @default.
• W2074089690 startingPage "436" @default.
• W2074089690 abstract "Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid-sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration. These systems jointly modulate U cell physiology, which adapts to nutrient limitations and utilize the nutrients released from L cells. Stress-resistant U cells share metabolic pathways and other similar characteristics with tumor cells, including the ability to proliferate. L cells behave similarly to stressed and starving cells, which activate degradative mechanisms to provide nutrients to U cells. Our data suggest a nutrient flow between both cell types, resembling the Cori cycle and glutamine-NH(4)(+) shuttle between tumor and healthy metazoan cells." @default.
• W2074089690 created "2016-06-24" @default.
• W2074089690 creator A5018175143 @default.
• W2074089690 creator A5055816371 @default.
• W2074089690 creator A5058570149 @default.
• W2074089690 creator A5063703555 @default.
• W2074089690 creator A5070832697 @default.
• W2074089690 date "2012-05-01" @default.
• W2074089690 modified "2023-10-18" @default.
• W2074089690 title "Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism" @default.
• W2074089690 cites W15212789 @default.
• W2074089690 cites W1536638573 @default.
• W2074089690 cites W1631944702 @default.
• W2074089690 cites W1634697921 @default.
• W2074089690 cites W1745777069 @default.
• W2074089690 cites W1966918880 @default.
• W2074089690 cites W1976107881 @default.
• W2074089690 cites W1985987305 @default.
• W2074089690 cites W2004975140 @default.
• W2074089690 cites W2006868369 @default.
• W2074089690 cites W2016231318 @default.
• W2074089690 cites W2022295226 @default.
• W2074089690 cites W2029868511 @default.
• W2074089690 cites W2044000506 @default.
• W2074089690 cites W2045200845 @default.
• W2074089690 cites W2048384173 @default.
• W2074089690 cites W2049665371 @default.
• W2074089690 cites W2050837145 @default.
• W2074089690 cites W2055628150 @default.
• W2074089690 cites W2060592426 @default.
• W2074089690 cites W2064813406 @default.
• W2074089690 cites W2089469061 @default.
• W2074089690 cites W2089904668 @default.
• W2074089690 cites W2090899899 @default.
• W2074089690 cites W2099830000 @default.
• W2074089690 cites W2099910467 @default.
• W2074089690 cites W2112771469 @default.
• W2074089690 cites W2117887677 @default.
• W2074089690 cites W2125025556 @default.
• W2074089690 cites W2131404785 @default.
• W2074089690 cites W2134224359 @default.
• W2074089690 cites W2142359121 @default.
• W2074089690 cites W2150910409 @default.
• W2074089690 cites W2156264079 @default.
• W2074089690 cites W2162023120 @default.
• W2074089690 doi "https://doi.org/10.1016/j.molcel.2012.04.001" @default.
• W2074089690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22560924" @default.
• W2074089690 hasPublicationYear "2012" @default.
• W2074089690 type Work @default.
• W2074089690 sameAs 2074089690 @default.
• W2074089690 citedByCount "108" @default.
• W2074089690 countsByYear W20740896902012 @default.
• W2074089690 countsByYear W20740896902013 @default.
• W2074089690 countsByYear W20740896902014 @default.
• W2074089690 countsByYear W20740896902015 @default.
• W2074089690 countsByYear W20740896902016 @default.
• W2074089690 countsByYear W20740896902017 @default.
• W2074089690 countsByYear W20740896902018 @default.
• W2074089690 countsByYear W20740896902019 @default.
• W2074089690 countsByYear W20740896902020 @default.
• W2074089690 countsByYear W20740896902021 @default.
• W2074089690 countsByYear W20740896902022 @default.
• W2074089690 countsByYear W20740896902023 @default.
• W2074089690 crossrefType "journal-article" @default.
• W2074089690 hasAuthorship W2074089690A5018175143 @default.
• W2074089690 hasAuthorship W2074089690A5055816371 @default.
• W2074089690 hasAuthorship W2074089690A5058570149 @default.
• W2074089690 hasAuthorship W2074089690A5063703555 @default.
• W2074089690 hasAuthorship W2074089690A5070832697 @default.
• W2074089690 hasBestOaLocation W20740896901 @default.
• W2074089690 hasConcept C137858568 @default.
• W2074089690 hasConcept C1491633281 @default.
• W2074089690 hasConcept C192989942 @default.
• W2074089690 hasConcept C2776030549 @default.
• W2074089690 hasConcept C2779222958 @default.
• W2074089690 hasConcept C2779349466 @default.
• W2074089690 hasConcept C515207424 @default.
• W2074089690 hasConcept C54355233 @default.
• W2074089690 hasConcept C55493867 @default.
• W2074089690 hasConcept C62112901 @default.
• W2074089690 hasConcept C62231903 @default.
• W2074089690 hasConcept C62478195 @default.
• W2074089690 hasConcept C74318829 @default.
• W2074089690 hasConcept C77255625 @default.
• W2074089690 hasConcept C86803240 @default.
• W2074089690 hasConcept C95444343 @default.
• W2074089690 hasConceptScore W2074089690C137858568 @default.
• W2074089690 hasConceptScore W2074089690C1491633281 @default.
• W2074089690 hasConceptScore W2074089690C192989942 @default.
• W2074089690 hasConceptScore W2074089690C2776030549 @default.
• W2074089690 hasConceptScore W2074089690C2779222958 @default.
• W2074089690 hasConceptScore W2074089690C2779349466 @default.
• W2074089690 hasConceptScore W2074089690C515207424 @default.
• W2074089690 hasConceptScore W2074089690C54355233 @default.
• W2074089690 hasConceptScore W2074089690C55493867 @default.
• W2074089690 hasConceptScore W2074089690C62112901 @default.
• W2074089690 hasConceptScore W2074089690C62231903 @default.
• W2074089690 hasConceptScore W2074089690C62478195 @default.

• next