FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074090413> ?p ?o ?g. }

• W2074090413 endingPage "e48802" @default.
• W2074090413 startingPage "e48802" @default.
• W2074090413 abstract "We present a computational, biophysical model of neuron-astrocyte-vessel interaction. Unlike other cells, neurons convey “hunger” signals to the vascular network via an intervening layer of glial cells (astrocytes); vessels dilate and release glucose which fuels neuronal firing. Existing computational models focus on only parts of this loop (neuron→astrocyte→vessel→neuron), whereas the proposed model describes the entire loop. Neuronal firing causes release of a neurotransmitter like glutamate which triggers release of vasodilator by astrocytes via a cascade of biochemical events. Vasodilators released from astrocytic endfeet cause blood vessels to dilate and release glucose into the interstitium, part of which is taken up by the astrocyticendfeet. Glucose is converted into lactate in the astrocyte and transported into the neuron. Glucose from the interstitium and lactate (produced from glucose) influx from astrocyte are converted into ATP in the neuron. Neuronal ATP is used to drive the Na+/K+ATPase pumps, which maintain ionic gradients necessary for neuronal firing. When placed in the metabolic loop, the neuron exhibits sustained firing only when the stimulation current is more than a minimum threshold. For various combinations of initial neuronal [ATP] and external current, the neuron exhibits a variety of firing patterns including sustained firing, firing after an initial pause, burst firing etc. Neurovascular interactions under conditions of constricted vessels are also studied. Most models of cerebral circulation describe neurovascular interactions exclusively in the “forward” neuron→vessel direction. The proposed model indicates possibility of “reverse” influence also, with vasomotion rhythms influencing neural firing patterns. Another idea that emerges out of the proposed work is that brain's computations may be more comprehensively understood in terms of neuro-glial-vascular dynamics and not in terms of neural firing alone." @default.
• W2074090413 created "2016-06-24" @default.
• W2074090413 creator A5011598453 @default.
• W2074090413 creator A5027520446 @default.
• W2074090413 date "2012-11-20" @default.
• W2074090413 modified "2023-10-06" @default.
• W2074090413 title "A Computational Model of Neuro-Glio-Vascular Loop Interactions" @default.
• W2074090413 cites W1575874727 @default.
• W2074090413 cites W1964119966 @default.
• W2074090413 cites W1977338273 @default.
• W2074090413 cites W1994497806 @default.
• W2074090413 cites W2003059369 @default.
• W2074090413 cites W2003728047 @default.
• W2074090413 cites W2006262508 @default.
• W2074090413 cites W2006581331 @default.
• W2074090413 cites W2016719895 @default.
• W2074090413 cites W2021091726 @default.
• W2074090413 cites W2021752702 @default.
• W2074090413 cites W2024778268 @default.
• W2074090413 cites W2042670485 @default.
• W2074090413 cites W2050717100 @default.
• W2074090413 cites W2051106202 @default.
• W2074090413 cites W2053154955 @default.
• W2074090413 cites W2058624548 @default.
• W2074090413 cites W2062549338 @default.
• W2074090413 cites W2070948004 @default.
• W2074090413 cites W2075748538 @default.
• W2074090413 cites W2082380332 @default.
• W2074090413 cites W2087575468 @default.
• W2074090413 cites W2095931805 @default.
• W2074090413 cites W2105050513 @default.
• W2074090413 cites W2106194191 @default.
• W2074090413 cites W2117490209 @default.
• W2074090413 cites W2137482772 @default.
• W2074090413 cites W2144734692 @default.
• W2074090413 cites W2151818004 @default.
• W2074090413 cites W2163234334 @default.
• W2074090413 cites W4206457422 @default.
• W2074090413 doi "https://doi.org/10.1371/journal.pone.0048802" @default.
• W2074090413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3502400" @default.
• W2074090413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23185276" @default.
• W2074090413 hasPublicationYear "2012" @default.
• W2074090413 type Work @default.
• W2074090413 sameAs 2074090413 @default.
• W2074090413 citedByCount "42" @default.
• W2074090413 countsByYear W20740904132013 @default.
• W2074090413 countsByYear W20740904132014 @default.
• W2074090413 countsByYear W20740904132015 @default.
• W2074090413 countsByYear W20740904132016 @default.
• W2074090413 countsByYear W20740904132017 @default.
• W2074090413 countsByYear W20740904132018 @default.
• W2074090413 countsByYear W20740904132019 @default.
• W2074090413 countsByYear W20740904132020 @default.
• W2074090413 countsByYear W20740904132021 @default.
• W2074090413 countsByYear W20740904132022 @default.
• W2074090413 countsByYear W20740904132023 @default.
• W2074090413 crossrefType "journal-article" @default.
• W2074090413 hasAuthorship W2074090413A5011598453 @default.
• W2074090413 hasAuthorship W2074090413A5027520446 @default.
• W2074090413 hasBestOaLocation W20740904131 @default.
• W2074090413 hasConcept C120770815 @default.
• W2074090413 hasConcept C12554922 @default.
• W2074090413 hasConcept C134018914 @default.
• W2074090413 hasConcept C169760540 @default.
• W2074090413 hasConcept C185592680 @default.
• W2074090413 hasConcept C2777542381 @default.
• W2074090413 hasConcept C2778794669 @default.
• W2074090413 hasConcept C529278444 @default.
• W2074090413 hasConcept C74254510 @default.
• W2074090413 hasConcept C86803240 @default.
• W2074090413 hasConceptScore W2074090413C120770815 @default.
• W2074090413 hasConceptScore W2074090413C12554922 @default.
• W2074090413 hasConceptScore W2074090413C134018914 @default.
• W2074090413 hasConceptScore W2074090413C169760540 @default.
• W2074090413 hasConceptScore W2074090413C185592680 @default.
• W2074090413 hasConceptScore W2074090413C2777542381 @default.
• W2074090413 hasConceptScore W2074090413C2778794669 @default.
• W2074090413 hasConceptScore W2074090413C529278444 @default.
• W2074090413 hasConceptScore W2074090413C74254510 @default.
• W2074090413 hasConceptScore W2074090413C86803240 @default.
• W2074090413 hasIssue "11" @default.
• W2074090413 hasLocation W20740904131 @default.
• W2074090413 hasLocation W20740904132 @default.
• W2074090413 hasLocation W20740904133 @default.
• W2074090413 hasLocation W20740904134 @default.
• W2074090413 hasLocation W20740904135 @default.
• W2074090413 hasOpenAccess W2074090413 @default.
• W2074090413 hasPrimaryLocation W20740904131 @default.
• W2074090413 hasRelatedWork W136829563 @default.
• W2074090413 hasRelatedWork W1994253577 @default.
• W2074090413 hasRelatedWork W2032730787 @default.
• W2074090413 hasRelatedWork W2132266804 @default.
• W2074090413 hasRelatedWork W2339909493 @default.
• W2074090413 hasRelatedWork W2561938851 @default.
• W2074090413 hasRelatedWork W2580929144 @default.
• W2074090413 hasRelatedWork W2755602000 @default.
• W2074090413 hasRelatedWork W3002370256 @default.
• W2074090413 hasRelatedWork W3178398029 @default.

• next