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• W2074091652 abstract "Add-on repetitive transcranial magnetic stimulation (rTMS) is effective in treating medication-resistant depression (MRD), but little is known about the rTMS antidepressant mechanism and pathophysiology underlying MRD.Twenty MRD patients received 2 weeks of navigated add-on rTMS to the left dorsolateral prefrontal cortex (DLPFC). Treatment response was defined as a ≥50% decrease in HDRS after treatment. Cerebral glucose metabolism was measured from all MRD patients twice, before and 3 months after rTMS, and from 20 healthy controls once at baseline.At baseline, MRD subjects presented significant hypometabolism at the bilateral DLPFC and anterior cingulum, as well as hypermetabolism at several limbic and subcortical regions compared to the controls. Higher metabolism at the medial PFC and rostral anterior cingulum, and lower metabolism at the limbic structures, including the left parahippocampus and fusiform gyrus, predicted a response to rTMS. After successful rTMS treatment, the abnormally elevated metabolism in the left middle temporal cortex and fusiform gyrus decreased significantly, suggesting a reversal of metabolic imbalances. However, the overall metabolic pattern was still abnormal, even after their depression was under control. In contrast, the non-responders showed a worsening pattern of increased metabolism in the bilateral temporal cortex and fusiform gyrus.The antidepressant mechanism of add-on rTMS may be reflected as suppression of hyperactivity in the left temporal cortex and fusiform gyrus, perhaps through enhancing the function of the medial prefrontal cortex and anterior cingulum. The limbic-cortical dysregulation of glucose metabolism might be a trait of an underlying mechanism of MRD." @default.
• W2074091652 created "2016-06-24" @default.
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• W2074091652 date "2010-12-01" @default.
• W2074091652 modified "2023-10-08" @default.
• W2074091652 title "Antidepressant mechanism of add-on repetitive transcranial magnetic stimulation in medication-resistant depression using cerebral glucose metabolism" @default.
• W2074091652 cites W1645771339 @default.
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• W2074091652 cites W1694363227 @default.
• W2074091652 cites W1964381474 @default.
• W2074091652 cites W1966123432 @default.
• W2074091652 cites W1969303073 @default.
• W2074091652 cites W1971972354 @default.
• W2074091652 cites W1972777532 @default.
• W2074091652 cites W1973587070 @default.
• W2074091652 cites W1975218877 @default.
• W2074091652 cites W1990701757 @default.
• W2074091652 cites W1996178564 @default.
• W2074091652 cites W1997245512 @default.
• W2074091652 cites W1997262444 @default.
• W2074091652 cites W1997284631 @default.
• W2074091652 cites W1997945733 @default.
• W2074091652 cites W2005690269 @default.
• W2074091652 cites W2016478370 @default.
• W2074091652 cites W2017831328 @default.
• W2074091652 cites W2022164261 @default.
• W2074091652 cites W2026904697 @default.
• W2074091652 cites W2027006914 @default.
• W2074091652 cites W2033760076 @default.
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• W2074091652 cites W2063122336 @default.
• W2074091652 cites W2065494735 @default.
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• W2074091652 doi "https://doi.org/10.1016/j.jad.2010.05.028" @default.
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