FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074092968> ?p ?o ?g. }

• W2074092968 endingPage "438" @default.
• W2074092968 startingPage "434" @default.
• W2074092968 abstract "Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression.The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis.Gastric specimens were obtained from 49 patients and histologically classified as: normal 10, superficial gastritis 14, chronic atrophic gastritis with intestinal metaplasia 15, and intestinal type of gastric carcinoma 10. Global DNA methylation was assessed by incubating DNA with (3H)-S-adenosylmethionine and Sss1 methylase. A higher incorporation of (3H) methyl groups reflects a lower degree of intrinsic methylation.A graduated increase in (3H) methyl group incorporation into DNA was found over the range extending from normal gastric mucosa, to superficial gastritis and to chronic atrophic gastritis (136,556 (24,085) v 235,725 (38,636) v 400,998 (26,747 dpm/micrograms/DNA respectively; p = 0.0002). No further increase was found in specimens from patients with carcinoma. No differences were found between extent of DNA methylation in neoplastic or non-neoplastic mucosa from patients with gastric carcinoma. Hypomethylation of DNA increased substantially with severe atrophy (p = 0.01) or with type III intestinal metaplasia (p = 0.15).Global DNA hypomethylation occurs in the early stages of gastric carcinogenesis, and it may be a novel biomarker of gastric neoplasia, useful in monitoring the response to chemopreventive agents." @default.
• W2074092968 created "2016-06-24" @default.
• W2074092968 creator A5003450488 @default.
• W2074092968 creator A5035608148 @default.
• W2074092968 creator A5046555614 @default.
• W2074092968 creator A5065822684 @default.
• W2074092968 creator A5080753533 @default.
• W2074092968 creator A5087683940 @default.
• W2074092968 creator A5091321763 @default.
• W2074092968 date "1996-09-01" @default.
• W2074092968 modified "2023-10-18" @default.
• W2074092968 title "Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma." @default.
• W2074092968 cites W100528328 @default.
• W2074092968 cites W1517038934 @default.
• W2074092968 cites W1522417671 @default.
• W2074092968 cites W1554775680 @default.
• W2074092968 cites W1893036907 @default.
• W2074092968 cites W1964959246 @default.
• W2074092968 cites W1967080684 @default.
• W2074092968 cites W1969373767 @default.
• W2074092968 cites W1969727351 @default.
• W2074092968 cites W1974359182 @default.
• W2074092968 cites W1978419388 @default.
• W2074092968 cites W1982689054 @default.
• W2074092968 cites W1986376221 @default.
• W2074092968 cites W1990111757 @default.
• W2074092968 cites W1994262939 @default.
• W2074092968 cites W2003781437 @default.
• W2074092968 cites W2004814909 @default.
• W2074092968 cites W2007476799 @default.
• W2074092968 cites W2016279068 @default.
• W2074092968 cites W2017268273 @default.
• W2074092968 cites W2020391792 @default.
• W2074092968 cites W2021109810 @default.
• W2074092968 cites W2029874395 @default.
• W2074092968 cites W2031129569 @default.
• W2074092968 cites W2043702960 @default.
• W2074092968 cites W2059713697 @default.
• W2074092968 cites W2071947369 @default.
• W2074092968 cites W2075684759 @default.
• W2074092968 cites W2080336014 @default.
• W2074092968 cites W2090205848 @default.
• W2074092968 cites W2106641597 @default.
• W2074092968 cites W2109856812 @default.
• W2074092968 cites W2114784597 @default.
• W2074092968 cites W2122871842 @default.
• W2074092968 cites W2130596897 @default.
• W2074092968 cites W2145337193 @default.
• W2074092968 cites W2145975061 @default.
• W2074092968 cites W2149493693 @default.
• W2074092968 cites W2160475471 @default.
• W2074092968 cites W2160504871 @default.
• W2074092968 cites W2204688295 @default.
• W2074092968 cites W2233205638 @default.
• W2074092968 cites W2338576041 @default.
• W2074092968 cites W308712928 @default.
• W2074092968 cites W32741228 @default.
• W2074092968 cites W4230088728 @default.
• W2074092968 cites W4230479687 @default.
• W2074092968 cites W4253344709 @default.
• W2074092968 doi "https://doi.org/10.1136/gut.39.3.434" @default.
• W2074092968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1383352" @default.
• W2074092968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8949650" @default.
• W2074092968 hasPublicationYear "1996" @default.
• W2074092968 type Work @default.
• W2074092968 sameAs 2074092968 @default.
• W2074092968 citedByCount "107" @default.
• W2074092968 countsByYear W20740929682012 @default.
• W2074092968 countsByYear W20740929682013 @default.
• W2074092968 countsByYear W20740929682014 @default.
• W2074092968 countsByYear W20740929682015 @default.
• W2074092968 countsByYear W20740929682016 @default.
• W2074092968 countsByYear W20740929682017 @default.
• W2074092968 countsByYear W20740929682019 @default.
• W2074092968 countsByYear W20740929682021 @default.
• W2074092968 crossrefType "journal-article" @default.
• W2074092968 hasAuthorship W2074092968A5003450488 @default.
• W2074092968 hasAuthorship W2074092968A5035608148 @default.
• W2074092968 hasAuthorship W2074092968A5046555614 @default.
• W2074092968 hasAuthorship W2074092968A5065822684 @default.
• W2074092968 hasAuthorship W2074092968A5080753533 @default.
• W2074092968 hasAuthorship W2074092968A5087683940 @default.
• W2074092968 hasAuthorship W2074092968A5091321763 @default.
• W2074092968 hasBestOaLocation W20740929681 @default.
• W2074092968 hasConcept C104317684 @default.
• W2074092968 hasConcept C121608353 @default.
• W2074092968 hasConcept C126322002 @default.
• W2074092968 hasConcept C142724271 @default.
• W2074092968 hasConcept C150194340 @default.
• W2074092968 hasConcept C190727270 @default.
• W2074092968 hasConcept C2776497702 @default.
• W2074092968 hasConcept C2777007973 @default.
• W2074092968 hasConcept C2777546739 @default.
• W2074092968 hasConcept C2778677798 @default.
• W2074092968 hasConcept C2779357193 @default.
• W2074092968 hasConcept C2779422922 @default.
• W2074092968 hasConcept C2780342937 @default.
• W2074092968 hasConcept C2781443798 @default.

• next