FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074094792> ?p ?o ?g. }

• W2074094792 endingPage "546" @default.
• W2074094792 startingPage "535" @default.
• W2074094792 abstract "The mechanism underlying the generation of cytosolic free Ca2+ ([Ca2+i) oscillations by bombesin, a receptor agonist activating phospholipase C, in insulin secreting HIT-T15 cells was investigated. At 25 μM, 61% of cells displayed [Ca2+]i oscillations with variable patterns. The bombesin-induced [Ca2+]i oscillations could last more than 1 h and glucose was required for maintaining these [Ca2+ fluctuations. Bombesin-evoked [Ca2+]i oscillations were dependent on extracellular Ca2+ entry and were attenuated by membrane hype rpolarization or by L-type Ca2+ channel blockers. These [Ca2+]i oscillations were apparently not associated with fluctuations in plasma membrane Ca2+ permeability as monitored by the Mn2+ quenching technique. 2,5-di-(tert-butyl)-1,4-benzohydroquinone (tBuBHQ) and 4-chloro-m-cresol, which interfere with intracellular Ca2+ stores, respectively, by inhibiting Ca2+-ATPase of endoplasmic reticulum and by affecting Ca2+-induced Ca2+ release, disrupted bombesin-induced [Ca2+]i oscillations. 4-chloro-m-resol raised [Ca2+]i by mobilizing an intracellular Ca2+ pool, an effect not altered by ryanodine. Caffeine exerted complex actions on [Ca2+]i It raised [Ca2+]i by promoting Ca2+ entry while inhibiting bombesin-elicited [Ca2+]i oscillations. Our results suggest that in bombesin-elicited [Ca2+]i oscillations in HIT-T15 cells: (i) the oscillations originate primarily from intracellular Ca2+ stores; and (ii) the Ca2+ influx required for maintaining the oscillations is in part membrane potential-sensitive and not coordinated with [Ca2+]i oscillations. The interplay between intracellular Ca2+ stores and voltage-sensitive and voltage-insensitive extracellular Ca2+ entry determines the [Ca2+]i oscillations evoked by bombesin." @default.
• W2074094792 created "2016-06-24" @default.
• W2074094792 creator A5027334799 @default.
• W2074094792 creator A5046030789 @default.
• W2074094792 creator A5072228093 @default.
• W2074094792 date "1996-06-01" @default.
• W2074094792 modified "2023-09-23" @default.
• W2074094792 title "Oscillations of cytosolic free calcium in bombesin-stimulated HIT-T15 cells" @default.
• W2074094792 cites W1490915687 @default.
• W2074094792 cites W1494239480 @default.
• W2074094792 cites W1498789021 @default.
• W2074094792 cites W1510877630 @default.
• W2074094792 cites W1531326750 @default.
• W2074094792 cites W1543532453 @default.
• W2074094792 cites W1553310373 @default.
• W2074094792 cites W1563562578 @default.
• W2074094792 cites W1576416454 @default.
• W2074094792 cites W1580644393 @default.
• W2074094792 cites W1590228583 @default.
• W2074094792 cites W1600993549 @default.
• W2074094792 cites W1602447595 @default.
• W2074094792 cites W1743153984 @default.
• W2074094792 cites W1759896623 @default.
• W2074094792 cites W1793072491 @default.
• W2074094792 cites W1794236190 @default.
• W2074094792 cites W1956859188 @default.
• W2074094792 cites W1978598042 @default.
• W2074094792 cites W1978778326 @default.
• W2074094792 cites W1983011541 @default.
• W2074094792 cites W1987461385 @default.
• W2074094792 cites W1993257524 @default.
• W2074094792 cites W1997093700 @default.
• W2074094792 cites W1998490733 @default.
• W2074094792 cites W2002441736 @default.
• W2074094792 cites W2002845695 @default.
• W2074094792 cites W2007219916 @default.
• W2074094792 cites W2020629288 @default.
• W2074094792 cites W2023234370 @default.
• W2074094792 cites W2027411301 @default.
• W2074094792 cites W2034218429 @default.
• W2074094792 cites W2036441475 @default.
• W2074094792 cites W2044187333 @default.
• W2074094792 cites W2064233348 @default.
• W2074094792 cites W2070993456 @default.
• W2074094792 cites W2071581935 @default.
• W2074094792 cites W2072484247 @default.
• W2074094792 cites W2075786190 @default.
• W2074094792 cites W2076210688 @default.
• W2074094792 cites W2080875376 @default.
• W2074094792 cites W2082857015 @default.
• W2074094792 cites W2103869501 @default.
• W2074094792 cites W2128270335 @default.
• W2074094792 cites W2153275719 @default.
• W2074094792 cites W2167452767 @default.
• W2074094792 cites W2174190166 @default.
• W2074094792 cites W2176847545 @default.
• W2074094792 cites W2218148748 @default.
• W2074094792 cites W58251843 @default.
• W2074094792 doi "https://doi.org/10.1016/s0143-4160(96)90063-9" @default.
• W2074094792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8842521" @default.
• W2074094792 hasPublicationYear "1996" @default.
• W2074094792 type Work @default.
• W2074094792 sameAs 2074094792 @default.
• W2074094792 citedByCount "17" @default.
• W2074094792 countsByYear W20740947922015 @default.
• W2074094792 crossrefType "journal-article" @default.
• W2074094792 hasAuthorship W2074094792A5027334799 @default.
• W2074094792 hasAuthorship W2074094792A5046030789 @default.
• W2074094792 hasAuthorship W2074094792A5072228093 @default.
• W2074094792 hasBestOaLocation W20740947922 @default.
• W2074094792 hasConcept C113217602 @default.
• W2074094792 hasConcept C118303440 @default.
• W2074094792 hasConcept C12554922 @default.
• W2074094792 hasConcept C126322002 @default.
• W2074094792 hasConcept C158617107 @default.
• W2074094792 hasConcept C170493617 @default.
• W2074094792 hasConcept C178790620 @default.
• W2074094792 hasConcept C181199279 @default.
• W2074094792 hasConcept C185592680 @default.
• W2074094792 hasConcept C2778448772 @default.
• W2074094792 hasConcept C28406088 @default.
• W2074094792 hasConcept C519063684 @default.
• W2074094792 hasConcept C55493867 @default.
• W2074094792 hasConcept C71924100 @default.
• W2074094792 hasConcept C79879829 @default.
• W2074094792 hasConcept C86803240 @default.
• W2074094792 hasConcept C95444343 @default.
• W2074094792 hasConcept C98539663 @default.
• W2074094792 hasConceptScore W2074094792C113217602 @default.
• W2074094792 hasConceptScore W2074094792C118303440 @default.
• W2074094792 hasConceptScore W2074094792C12554922 @default.
• W2074094792 hasConceptScore W2074094792C126322002 @default.
• W2074094792 hasConceptScore W2074094792C158617107 @default.
• W2074094792 hasConceptScore W2074094792C170493617 @default.
• W2074094792 hasConceptScore W2074094792C178790620 @default.
• W2074094792 hasConceptScore W2074094792C181199279 @default.
• W2074094792 hasConceptScore W2074094792C185592680 @default.
• W2074094792 hasConceptScore W2074094792C2778448772 @default.

• next