FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074095710> ?p ?o ?g. }

• W2074095710 endingPage "914" @default.
• W2074095710 startingPage "908" @default.
• W2074095710 abstract "1. In the present study, we investigated the impact of 1.0% ropivacaine on the ultrastructure and proteome of the rat spinal cord.2. Rats received three injections (90-min intervals, 0.2 mL/kg) of 0.9% NaCl, 0.5% ropivacaine or 1.0% ropivacaine via an implanted intrathecal catheter. Transmission electron microscopy was performed to exam the ultrastructure of the spinal cord. Two-dimensional electrophoresis followed by mass spectrometry identification were carried out to investigate the proteome.3. In the rats administered 1.0% ropivacaine, deformed organelles, detached myelinated nerve fiber layer, and incomplete inner and outer shaft membranes were observed in the spinal cord and posterior root shrunken nuclei. Furthermore, in the rat spinal cord 1.0% ropivacaine induced the down-regulation of voltage-dependent anion channel 2 (VDAC2) and mitochondrial pyruvate dehydrogenase subunit alpha (ODPA), the upregulation of myelin basic protein (MBP), the disappearance of myelin transcription factor 1 (MYT1) and the appearance of heat shock protein 25 (HSP25). Little change was observed in the 0.5% ropivacaine or control groups.4. Our results suggest that 1.0% ropivacaine treatment led to neurotoxicity, as shown by ultrastructural and proteomic changes in the rat spinal cord. Specific proteins were identified that are implicated in 1.0% ropivacaine-induced neurotoxicity." @default.
• W2074095710 created "2016-06-24" @default.
• W2074095710 creator A5001604900 @default.
• W2074095710 creator A5058965019 @default.
• W2074095710 creator A5065933735 @default.
• W2074095710 creator A5085180517 @default.
• W2074095710 date "2013-03-28" @default.
• W2074095710 modified "2023-10-16" @default.
• W2074095710 title "Injection of ropivacaine into the subarachnoid changes the ultrastructure and proteome of the rat spinal cord" @default.
• W2074095710 cites W1972476140 @default.
• W2074095710 cites W1983000118 @default.
• W2074095710 cites W1983871097 @default.
• W2074095710 cites W2003565267 @default.
• W2074095710 cites W2013536337 @default.
• W2074095710 cites W2028064980 @default.
• W2074095710 cites W2040725197 @default.
• W2074095710 cites W2043433277 @default.
• W2074095710 cites W2057958952 @default.
• W2074095710 cites W2059645144 @default.
• W2074095710 cites W2071296558 @default.
• W2074095710 cites W2071341582 @default.
• W2074095710 cites W2079223821 @default.
• W2074095710 cites W2081644047 @default.
• W2074095710 cites W2083587797 @default.
• W2074095710 cites W2110832151 @default.
• W2074095710 cites W2131656918 @default.
• W2074095710 cites W2158405633 @default.
• W2074095710 cites W2165192246 @default.
• W2074095710 cites W2239949069 @default.
• W2074095710 cites W2395259309 @default.
• W2074095710 cites W3142600377 @default.
• W2074095710 cites W4229625171 @default.
• W2074095710 cites W4251077622 @default.
• W2074095710 cites W4256074949 @default.
• W2074095710 doi "https://doi.org/10.3109/00498254.2013.782454" @default.
• W2074095710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23536973" @default.
• W2074095710 hasPublicationYear "2013" @default.
• W2074095710 type Work @default.
• W2074095710 sameAs 2074095710 @default.
• W2074095710 citedByCount "7" @default.
• W2074095710 countsByYear W20740957102014 @default.
• W2074095710 countsByYear W20740957102019 @default.
• W2074095710 countsByYear W20740957102021 @default.
• W2074095710 countsByYear W20740957102023 @default.
• W2074095710 crossrefType "journal-article" @default.
• W2074095710 hasAuthorship W2074095710A5001604900 @default.
• W2074095710 hasAuthorship W2074095710A5058965019 @default.
• W2074095710 hasAuthorship W2074095710A5065933735 @default.
• W2074095710 hasAuthorship W2074095710A5085180517 @default.
• W2074095710 hasConcept C104292427 @default.
• W2074095710 hasConcept C104317684 @default.
• W2074095710 hasConcept C104397665 @default.
• W2074095710 hasConcept C105702510 @default.
• W2074095710 hasConcept C134018914 @default.
• W2074095710 hasConcept C169760540 @default.
• W2074095710 hasConcept C185592680 @default.
• W2074095710 hasConcept C2778609137 @default.
• W2074095710 hasConcept C2780269707 @default.
• W2074095710 hasConcept C2780775167 @default.
• W2074095710 hasConcept C42219234 @default.
• W2074095710 hasConcept C529278444 @default.
• W2074095710 hasConcept C55493867 @default.
• W2074095710 hasConcept C71924100 @default.
• W2074095710 hasConcept C86803240 @default.
• W2074095710 hasConceptScore W2074095710C104292427 @default.
• W2074095710 hasConceptScore W2074095710C104317684 @default.
• W2074095710 hasConceptScore W2074095710C104397665 @default.
• W2074095710 hasConceptScore W2074095710C105702510 @default.
• W2074095710 hasConceptScore W2074095710C134018914 @default.
• W2074095710 hasConceptScore W2074095710C169760540 @default.
• W2074095710 hasConceptScore W2074095710C185592680 @default.
• W2074095710 hasConceptScore W2074095710C2778609137 @default.
• W2074095710 hasConceptScore W2074095710C2780269707 @default.
• W2074095710 hasConceptScore W2074095710C2780775167 @default.
• W2074095710 hasConceptScore W2074095710C42219234 @default.
• W2074095710 hasConceptScore W2074095710C529278444 @default.
• W2074095710 hasConceptScore W2074095710C55493867 @default.
• W2074095710 hasConceptScore W2074095710C71924100 @default.
• W2074095710 hasConceptScore W2074095710C86803240 @default.
• W2074095710 hasIssue "10" @default.
• W2074095710 hasLocation W20740957101 @default.
• W2074095710 hasLocation W20740957102 @default.
• W2074095710 hasOpenAccess W2074095710 @default.
• W2074095710 hasPrimaryLocation W20740957101 @default.
• W2074095710 hasRelatedWork W1972992758 @default.
• W2074095710 hasRelatedWork W2004130834 @default.
• W2074095710 hasRelatedWork W2029742622 @default.
• W2074095710 hasRelatedWork W2031386591 @default.
• W2074095710 hasRelatedWork W2050415048 @default.
• W2074095710 hasRelatedWork W2341139697 @default.
• W2074095710 hasRelatedWork W2395677346 @default.
• W2074095710 hasRelatedWork W2465599291 @default.
• W2074095710 hasRelatedWork W2470375221 @default.
• W2074095710 hasRelatedWork W2887389637 @default.
• W2074095710 hasVolume "43" @default.
• W2074095710 isParatext "false" @default.
• W2074095710 isRetracted "false" @default.
• W2074095710 magId "2074095710" @default.

• next