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- W2074103669 abstract "Abstract: The molecular reaction patterns of the DRw52-specific mouse monoclonal antibodies UL-52 and 7.3.19.1 were investigated. Upon immunoprecipitation and two-dimensional IEF-SDS polyacrylamide gel electrophoresis analysis (2D-PAGE) mAb UL-52 selectively isolated DRβ1 molecules from DRw52-positive cell lines, whereas mAb 7.3.19.1 predominantly precipitated DRβ3 molecules. Reduced mAb UL-52 binding affinity was observed to DRw8- and DRwl2-positive cells, potentially resulting from structural modifications within the antibody binding site. Comparison of mAb UL-52 reactivity with published DRβ chain amino acid sequences demonstrates that the amino acid residues -S- in positions 11 and 13 on DRβ1 molecules essentially contribute to the formation of the antibody binding site. mAb 7.3.19.1 reactivity, on the other hand, correlates with the expression of DRβ3 chain amino acid residues K, G and N, in positions 71, 73 and 77, respectively. In contrast to other DRw52 monoclonal antibodies described so far, mAb UL-52 demonstrates a similar reactivity to DRw52 allosera, suggesting that mAb UL-52 and DRw52 allosera possibly recognize the same or a similar determinant on DRβ1 molecules." @default.
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- W2074103669 date "1990-11-01" @default.
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- W2074103669 title "Mapping of an HLA-DRw52-associated determinant on DRβ1 molecules" @default.
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- W2074103669 doi "https://doi.org/10.1111/j.1399-0039.1990.tb01828.x" @default.
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