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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074103997> ?p ?o ?g. }

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• W2074103997 abstract "Cellular senescence is widely believed to play a key role in tumor suppression, but the molecular pathways that regulate senescence are only incompletely understood. By using a secretome proteomics approach, we identified insulin-like growth factor binding protein 3 (IGFBP3) as a secreted mediator of breast cancer senescence upon chemotherapeutic drug treatment. The senescence-inducing activity of IGFBP3 is inhibited by tissue-type plasminogen activator-mediated proteolysis, which is counteracted by plasminogen activator inhibitor 1 (PAI-1), another secreted mediator of senescence. We demonstrate that IGFBP3 is a critical downstream target of PAI-1-induced senescence. These results suggest a role for an extracellular cascade of secreted proteins in the regulation of cellular senescence." @default.
• W2074103997 created "2016-06-24" @default.
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• W2074103997 date "2012-07-09" @default.
• W2074103997 modified "2023-10-16" @default.
• W2074103997 title "Plasminogen activator inhibitor 1 - insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence" @default.
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• W2074103997 doi "https://doi.org/10.1073/pnas.1120437109" @default.
• W2074103997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3409757" @default.
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