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• W2074132622 abstract "Today, there is increasing evidence that PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>activators mediate their antimigratory and anti-invasive properties remains elusive. This letter gives a short review on the debate and adds to the current knowledge by applying a PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>independent manner." @default.
• W2074132622 created "2016-06-24" @default.
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• W2074132622 date "2008-01-01" @default.
• W2074132622 modified "2023-10-03" @default.
• W2074132622 title "PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion" @default.
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• W2074132622 doi "https://doi.org/10.1155/2008/513943" @default.
• W2074132622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2542841" @default.
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