FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074138272> ?p ?o ?g. }

• W2074138272 endingPage "106" @default.
• W2074138272 startingPage "96" @default.
• W2074138272 abstract "The use of disodium ethane-1 hydroxy-1, 1-diphosphonate (EHDP) therapy for Paget's disease of bone was examined in 75 affected patients. Forty-eight patients received randomly assigned oral doses of either 0, 2.5, 5, 10, or 20 mg/kg/day in a controlled, double-blind protocol, and the remainder received either 10 or 20 mg/kg/day in a non-random protocol. The clinical status of the patients and appropriate laboratory tests were evaluated before treatment and at frequent intervals during a six-month period of initial therapy. There were no significant changes in either urinary hydroxyproline or serum alkaline phosphatase in those patients receiving placebos, while both these parameters decreased significantly at all dose levels of EHDP, with the greatest decline noted in the highest dose group. However, statistical analysis of the data related to changes in symptoms in the double-blind study revealed that patients receiving the higher dose of EHDP (10 or 20 mg/kg/day) had less favorable outcomes than those receiving the lower doses (2.5 or 5 mg/kg/day). The high does group had a relatively lower rate of symptom improvement and a relatively greater rate of deterioration than did the low dose group. Twenty-one of forty-nine patients followed for at least 18 months have shown a sustained suppression of their serum alkaline phosphatase and urinary hydroxyproline values for 12 months following cessation of EHDP, while therapy has been reinstituted for the other 28 patients because of increases in these measurements, with or without accompanying symptomatic deterioration. Eight patients sustained fractures through Pagetic bone during the period of study and all of these were treated with higher doses of EHDP. On the basis of the biochemical and clinical data in this study it appears that initial therapy of Paget's disease of bone with 5 mg EHDP/kg/day maximizes benefits while minimizing possible adverse effects." @default.
• W2074138272 created "2016-06-24" @default.
• W2074138272 creator A5000336194 @default.
• W2074138272 creator A5001864791 @default.
• W2074138272 creator A5012444329 @default.
• W2074138272 creator A5012729779 @default.
• W2074138272 creator A5014095626 @default.
• W2074138272 creator A5018359159 @default.
• W2074138272 creator A5026064645 @default.
• W2074138272 creator A5042413704 @default.
• W2074138272 creator A5042995041 @default.
• W2074138272 creator A5059057793 @default.
• W2074138272 date "1977-01-01" @default.
• W2074138272 modified "2023-10-10" @default.
• W2074138272 title "Diphosphonate Therapy of Paget's Disease of Bone" @default.
• W2074138272 cites W142992303 @default.
• W2074138272 cites W1494806282 @default.
• W2074138272 cites W1508831547 @default.
• W2074138272 cites W1531901232 @default.
• W2074138272 cites W174194710 @default.
• W2074138272 cites W1987349542 @default.
• W2074138272 cites W1992173458 @default.
• W2074138272 cites W1993136364 @default.
• W2074138272 cites W2000727929 @default.
• W2074138272 cites W2031378545 @default.
• W2074138272 cites W2037185199 @default.
• W2074138272 cites W2047467283 @default.
• W2074138272 cites W2048681811 @default.
• W2074138272 cites W2050063000 @default.
• W2074138272 cites W2085764861 @default.
• W2074138272 cites W2130289134 @default.
• W2074138272 cites W2313084937 @default.
• W2074138272 cites W2337075852 @default.
• W2074138272 cites W2399281465 @default.
• W2074138272 cites W2407570615 @default.
• W2074138272 cites W2466966419 @default.
• W2074138272 cites W2474045298 @default.
• W2074138272 cites W2757643525 @default.
• W2074138272 cites W896614683 @default.
• W2074138272 doi "https://doi.org/10.1210/jcem-44-1-96" @default.
• W2074138272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/401827" @default.
• W2074138272 hasPublicationYear "1977" @default.
• W2074138272 type Work @default.
• W2074138272 sameAs 2074138272 @default.
• W2074138272 citedByCount "157" @default.
• W2074138272 countsByYear W20741382722012 @default.
• W2074138272 countsByYear W20741382722013 @default.
• W2074138272 countsByYear W20741382722015 @default.
• W2074138272 countsByYear W20741382722017 @default.
• W2074138272 countsByYear W20741382722019 @default.
• W2074138272 crossrefType "journal-article" @default.
• W2074138272 hasAuthorship W2074138272A5000336194 @default.
• W2074138272 hasAuthorship W2074138272A5001864791 @default.
• W2074138272 hasAuthorship W2074138272A5012444329 @default.
• W2074138272 hasAuthorship W2074138272A5012729779 @default.
• W2074138272 hasAuthorship W2074138272A5014095626 @default.
• W2074138272 hasAuthorship W2074138272A5018359159 @default.
• W2074138272 hasAuthorship W2074138272A5026064645 @default.
• W2074138272 hasAuthorship W2074138272A5042413704 @default.
• W2074138272 hasAuthorship W2074138272A5042995041 @default.
• W2074138272 hasAuthorship W2074138272A5059057793 @default.
• W2074138272 hasConcept C126322002 @default.
• W2074138272 hasConcept C126894567 @default.
• W2074138272 hasConcept C134018914 @default.
• W2074138272 hasConcept C160160445 @default.
• W2074138272 hasConcept C181199279 @default.
• W2074138272 hasConcept C185592680 @default.
• W2074138272 hasConcept C2776154862 @default.
• W2074138272 hasConcept C2776541429 @default.
• W2074138272 hasConcept C2779134260 @default.
• W2074138272 hasConcept C2779797417 @default.
• W2074138272 hasConcept C2781104859 @default.
• W2074138272 hasConcept C55493867 @default.
• W2074138272 hasConcept C65409693 @default.
• W2074138272 hasConcept C71924100 @default.
• W2074138272 hasConcept C77411442 @default.
• W2074138272 hasConcept C90924648 @default.
• W2074138272 hasConceptScore W2074138272C126322002 @default.
• W2074138272 hasConceptScore W2074138272C126894567 @default.
• W2074138272 hasConceptScore W2074138272C134018914 @default.
• W2074138272 hasConceptScore W2074138272C160160445 @default.
• W2074138272 hasConceptScore W2074138272C181199279 @default.
• W2074138272 hasConceptScore W2074138272C185592680 @default.
• W2074138272 hasConceptScore W2074138272C2776154862 @default.
• W2074138272 hasConceptScore W2074138272C2776541429 @default.
• W2074138272 hasConceptScore W2074138272C2779134260 @default.
• W2074138272 hasConceptScore W2074138272C2779797417 @default.
• W2074138272 hasConceptScore W2074138272C2781104859 @default.
• W2074138272 hasConceptScore W2074138272C55493867 @default.
• W2074138272 hasConceptScore W2074138272C65409693 @default.
• W2074138272 hasConceptScore W2074138272C71924100 @default.
• W2074138272 hasConceptScore W2074138272C77411442 @default.
• W2074138272 hasConceptScore W2074138272C90924648 @default.
• W2074138272 hasIssue "1" @default.
• W2074138272 hasLocation W20741382721 @default.
• W2074138272 hasLocation W20741382722 @default.
• W2074138272 hasOpenAccess W2074138272 @default.
• W2074138272 hasPrimaryLocation W20741382721 @default.

• next