FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074143852> ?p ?o ?g. }

• W2074143852 endingPage "117" @default.
• W2074143852 startingPage "117" @default.
• W2074143852 abstract "Myelination of peripheral nerves by Schwann cells requires not only the Egr2/Krox-20 transactivator, but also the NGFI-A/Egr-binding (NAB) corepressors, which modulate activity of Egr2. Previous work has shown that axon-dependent expression of Egr2 is mediated by neuregulin stimulation, and NAB corepressors are co-regulated with Egr2 expression in peripheral nerve development. NAB corepressors have also been implicated in macrophage development, cardiac hypertrophy, prostate carcinogenesis, and feedback regulation involved in hindbrain development.To test the mechanism of NAB regulation in Schwann cells, transfection assays revealed that both Nab1 and Nab2 promoters are activated by Egr2 expression. Furthermore, direct binding of Egr2 at these promoters was demonstrated in vivo by chromatin immunoprecipitation analysis of myelinating sciatic nerve, and binding of Egr2 to the Nab2 promoter was stimulated by neuregulin in primary Schwann cells. Although Egr2 expression activates the Nab2 promoter more highly than Nab1, we surprisingly found that only Nab1 - but not Nab2 - expression levels were reduced in sciatic nerve from Egr2 null mice. Analysis of the Nab2 promoter showed that it is also activated by ETS proteins (Ets2 and Etv1/ER81) and is bound by Ets2 in vivo.Overall, these results indicate that induction of Nab2 expression in Schwann cells involves not only Egr2, but also ETS proteins that are activated by neuregulin stimulation. Although Nab1 and Nab2 play partially redundant roles, regulation of Nab2 expression by ETS factors explains several observations regarding regulation of NAB genes. Finally, these data suggest that NAB proteins are not only feedback inhibitors of Egr2, but rather that co-induction of Egr2 and NAB genes is involved in forming an Egr2/NAB complex that is crucial for regulation of gene expression." @default.
• W2074143852 created "2016-06-24" @default.
• W2074143852 creator A5023365864 @default.
• W2074143852 creator A5025054004 @default.
• W2074143852 creator A5027767206 @default.
• W2074143852 creator A5036320437 @default.
• W2074143852 creator A5044814535 @default.
• W2074143852 creator A5088175315 @default.
• W2074143852 date "2007-01-01" @default.
• W2074143852 modified "2023-10-15" @default.
• W2074143852 title "Differential regulation of NAB corepressor genes in Schwann cells" @default.
• W2074143852 cites W155450808 @default.
• W2074143852 cites W1567559129 @default.
• W2074143852 cites W1665419471 @default.
• W2074143852 cites W1938043420 @default.
• W2074143852 cites W1964571549 @default.
• W2074143852 cites W1969526312 @default.
• W2074143852 cites W1974324106 @default.
• W2074143852 cites W1976731473 @default.
• W2074143852 cites W1977383995 @default.
• W2074143852 cites W1982724357 @default.
• W2074143852 cites W1984580777 @default.
• W2074143852 cites W1991528006 @default.
• W2074143852 cites W1991703596 @default.
• W2074143852 cites W1998279268 @default.
• W2074143852 cites W2000045473 @default.
• W2074143852 cites W2001352795 @default.
• W2074143852 cites W2005901626 @default.
• W2074143852 cites W2006345574 @default.
• W2074143852 cites W2014848658 @default.
• W2074143852 cites W2017396706 @default.
• W2074143852 cites W2028934778 @default.
• W2074143852 cites W2029322715 @default.
• W2074143852 cites W2029537608 @default.
• W2074143852 cites W2030248303 @default.
• W2074143852 cites W2040394644 @default.
• W2074143852 cites W2041798139 @default.
• W2074143852 cites W2044570331 @default.
• W2074143852 cites W2047342629 @default.
• W2074143852 cites W2050374121 @default.
• W2074143852 cites W2053622253 @default.
• W2074143852 cites W2055614967 @default.
• W2074143852 cites W2056594032 @default.
• W2074143852 cites W2056714530 @default.
• W2074143852 cites W2056863695 @default.
• W2074143852 cites W2057848210 @default.
• W2074143852 cites W2065010411 @default.
• W2074143852 cites W2065505689 @default.
• W2074143852 cites W2066192820 @default.
• W2074143852 cites W2067298439 @default.
• W2074143852 cites W2069781030 @default.
• W2074143852 cites W2074155226 @default.
• W2074143852 cites W2078008577 @default.
• W2074143852 cites W2081422655 @default.
• W2074143852 cites W2093182308 @default.
• W2074143852 cites W2102718676 @default.
• W2074143852 cites W2103179205 @default.
• W2074143852 cites W2107277218 @default.
• W2074143852 cites W2113404473 @default.
• W2074143852 cites W2116547262 @default.
• W2074143852 cites W2118156146 @default.
• W2074143852 cites W2123995229 @default.
• W2074143852 cites W2126947711 @default.
• W2074143852 cites W2129955844 @default.
• W2074143852 cites W2131589770 @default.
• W2074143852 cites W2133736050 @default.
• W2074143852 cites W2138604866 @default.
• W2074143852 cites W2145599313 @default.
• W2074143852 cites W2150901931 @default.
• W2074143852 cites W2151642254 @default.
• W2074143852 cites W2151818773 @default.
• W2074143852 cites W2153726199 @default.
• W2074143852 cites W2156142598 @default.
• W2074143852 cites W2162404977 @default.
• W2074143852 cites W2165625463 @default.
• W2074143852 cites W2170487338 @default.
• W2074143852 cites W2170677539 @default.
• W2074143852 cites W2325780118 @default.
• W2074143852 cites W2079936753 @default.
• W2074143852 doi "https://doi.org/10.1186/1471-2199-8-117" @default.
• W2074143852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2235890" @default.
• W2074143852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18096076" @default.
• W2074143852 hasPublicationYear "2007" @default.
• W2074143852 type Work @default.
• W2074143852 sameAs 2074143852 @default.
• W2074143852 citedByCount "19" @default.
• W2074143852 countsByYear W20741438522012 @default.
• W2074143852 countsByYear W20741438522013 @default.
• W2074143852 countsByYear W20741438522014 @default.
• W2074143852 countsByYear W20741438522016 @default.
• W2074143852 countsByYear W20741438522017 @default.
• W2074143852 countsByYear W20741438522018 @default.
• W2074143852 countsByYear W20741438522020 @default.
• W2074143852 countsByYear W20741438522021 @default.
• W2074143852 crossrefType "journal-article" @default.
• W2074143852 hasAuthorship W2074143852A5023365864 @default.
• W2074143852 hasAuthorship W2074143852A5025054004 @default.
• W2074143852 hasAuthorship W2074143852A5027767206 @default.

• next