FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074144362> ?p ?o ?g. }

• W2074144362 endingPage "24825" @default.
• W2074144362 startingPage "24813" @default.
• W2074144362 abstract "In yeast, Tim50 along with Tim23 regulate translocation of presequence-containing proteins across the mitochondrial inner membrane. Here, we describe the identification and characterization of a novel human mitochondrial inner membrane protein homologous to the yeast Tim50. We demonstrate that human Tim50 possesses phosphatase activity and is present in a complex with human Tim23. Down-regulation of human Tim50 expression by RNA interference increases the sensitivity of human cell lines to death stimuli by accelerating the release of cytochrome c from the mitochondria. Furthermore, injection of Tim50-specific morpholino antisense oligonucleotides during early zebrafish embryonic development causes neurodegeneration, dysmorphic hearts, and reduced motility as a result of increased cell death. These observations indicate that loss of Tim50 in vertebrates causes mitochondrial membrane permeabilization and dysfunction followed by cytoplasmic release of cytochrome c along with other mitochondrial inducers of cell death. Thus Tim50 is important for both mitochondrial function and early neuronal development. In yeast, Tim50 along with Tim23 regulate translocation of presequence-containing proteins across the mitochondrial inner membrane. Here, we describe the identification and characterization of a novel human mitochondrial inner membrane protein homologous to the yeast Tim50. We demonstrate that human Tim50 possesses phosphatase activity and is present in a complex with human Tim23. Down-regulation of human Tim50 expression by RNA interference increases the sensitivity of human cell lines to death stimuli by accelerating the release of cytochrome c from the mitochondria. Furthermore, injection of Tim50-specific morpholino antisense oligonucleotides during early zebrafish embryonic development causes neurodegeneration, dysmorphic hearts, and reduced motility as a result of increased cell death. These observations indicate that loss of Tim50 in vertebrates causes mitochondrial membrane permeabilization and dysfunction followed by cytoplasmic release of cytochrome c along with other mitochondrial inducers of cell death. Thus Tim50 is important for both mitochondrial function and early neuronal development." @default.
• W2074144362 created "2016-06-24" @default.
• W2074144362 creator A5007870500 @default.
• W2074144362 creator A5025821252 @default.
• W2074144362 creator A5037627141 @default.
• W2074144362 creator A5039081372 @default.
• W2074144362 creator A5065523014 @default.
• W2074144362 creator A5069095259 @default.
• W2074144362 creator A5072313662 @default.
• W2074144362 creator A5077708146 @default.
• W2074144362 date "2004-06-01" @default.
• W2074144362 modified "2023-10-01" @default.
• W2074144362 title "Tim50, a Component of the Mitochondrial Translocator, Regulates Mitochondrial Integrity and Cell Death" @default.
• W2074144362 cites W1480948328 @default.
• W2074144362 cites W1492587973 @default.
• W2074144362 cites W1506642042 @default.
• W2074144362 cites W1540720871 @default.
• W2074144362 cites W1618299283 @default.
• W2074144362 cites W163606371 @default.
• W2074144362 cites W1964332543 @default.
• W2074144362 cites W1965591721 @default.
• W2074144362 cites W1966176339 @default.
• W2074144362 cites W1966291495 @default.
• W2074144362 cites W1966798559 @default.
• W2074144362 cites W1968854074 @default.
• W2074144362 cites W1970834072 @default.
• W2074144362 cites W1980699864 @default.
• W2074144362 cites W1985721503 @default.
• W2074144362 cites W1991076291 @default.
• W2074144362 cites W1998756807 @default.
• W2074144362 cites W1999145879 @default.
• W2074144362 cites W2001150129 @default.
• W2074144362 cites W2002926498 @default.
• W2074144362 cites W2009885873 @default.
• W2074144362 cites W2013504014 @default.
• W2074144362 cites W2015025581 @default.
• W2074144362 cites W2019830107 @default.
• W2074144362 cites W2020220420 @default.
• W2074144362 cites W2027325631 @default.
• W2074144362 cites W2030401341 @default.
• W2074144362 cites W2030573603 @default.
• W2074144362 cites W2039276913 @default.
• W2074144362 cites W2042409437 @default.
• W2074144362 cites W2042728467 @default.
• W2074144362 cites W2042779695 @default.
• W2074144362 cites W2054488866 @default.
• W2074144362 cites W2064819482 @default.
• W2074144362 cites W2072836045 @default.
• W2074144362 cites W2075352602 @default.
• W2074144362 cites W2075384741 @default.
• W2074144362 cites W2077701124 @default.
• W2074144362 cites W2083998249 @default.
• W2074144362 cites W2086165161 @default.
• W2074144362 cites W2087296674 @default.
• W2074144362 cites W2087450028 @default.
• W2074144362 cites W2090226049 @default.
• W2074144362 cites W2094077760 @default.
• W2074144362 cites W2097767970 @default.
• W2074144362 cites W2102443458 @default.
• W2074144362 cites W2110075925 @default.
• W2074144362 cites W2120418365 @default.
• W2074144362 cites W2121658651 @default.
• W2074144362 cites W2129231604 @default.
• W2074144362 cites W2131143886 @default.
• W2074144362 cites W2147787249 @default.
• W2074144362 cites W2153689486 @default.
• W2074144362 cites W2153747430 @default.
• W2074144362 cites W2154949807 @default.
• W2074144362 cites W2159403505 @default.
• W2074144362 cites W2159650080 @default.
• W2074144362 cites W2162653594 @default.
• W2074144362 cites W2173390200 @default.
• W2074144362 cites W2462855682 @default.
• W2074144362 cites W2472043891 @default.
• W2074144362 cites W4376848558 @default.
• W2074144362 doi "https://doi.org/10.1074/jbc.m402049200" @default.
• W2074144362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15044455" @default.
• W2074144362 hasPublicationYear "2004" @default.
• W2074144362 type Work @default.
• W2074144362 sameAs 2074144362 @default.
• W2074144362 citedByCount "91" @default.
• W2074144362 countsByYear W20741443622012 @default.
• W2074144362 countsByYear W20741443622013 @default.
• W2074144362 countsByYear W20741443622014 @default.
• W2074144362 countsByYear W20741443622015 @default.
• W2074144362 countsByYear W20741443622016 @default.
• W2074144362 countsByYear W20741443622017 @default.
• W2074144362 countsByYear W20741443622018 @default.
• W2074144362 countsByYear W20741443622019 @default.
• W2074144362 countsByYear W20741443622020 @default.
• W2074144362 countsByYear W20741443622021 @default.
• W2074144362 countsByYear W20741443622022 @default.
• W2074144362 countsByYear W20741443622023 @default.
• W2074144362 crossrefType "journal-article" @default.
• W2074144362 hasAuthorship W2074144362A5007870500 @default.
• W2074144362 hasAuthorship W2074144362A5025821252 @default.
• W2074144362 hasAuthorship W2074144362A5037627141 @default.
• W2074144362 hasAuthorship W2074144362A5039081372 @default.

• next