FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074156639> ?p ?o ?g. }

• W2074156639 endingPage "2475" @default.
• W2074156639 startingPage "2466" @default.
• W2074156639 abstract "The cellular c- myb gene encodes a transcription factor composed of a DNA-binding domain, a transactivating domain and a regulatory domain located at its carboxy (C-) terminus. The latter one is deleted in the transforming viral protein v-Myb. Here we show that deletion of the C-terminus of c-Myb increases the transcriptional transactivation activity of c-Myb defining it as cis -acting negative regulatory domain. Cotransfection of the Cterminus in an in vivo competition assay causes stimulation of the transcriptional activity of various vand c-Myb expression constructs in trans . The effect is dose-dependent and independent of the kind of DNAbinding domain, since c-Myb as well as GAL4-c-Myb chimaeras can be stimulated in trans . Other transcription factors, such as GAL4-VP16, GAL4, c-Jun or C/EBPβ are also stimulated by the cotransfected Cterminus. In contrast, human B-Myb is not stimulated by the c-Myb C-terminus in trans . The data suggest that the C-terminus of c-Myb may interact with a cellular inhibitor which is part of the protein complex mediating activated transcription and may stimulate in trans by sequestering away such an inhibitor. Binding of c-Myb to a putative inhibitor would explain differences between c-Myb in comparison to B- and v-Myb in transcriptional regulation." @default.
• W2074156639 created "2016-06-24" @default.
• W2074156639 creator A5049872530 @default.
• W2074156639 creator A5071063397 @default.
• W2074156639 creator A5074422772 @default.
• W2074156639 creator A5090218748 @default.
• W2074156639 date "1994-01-01" @default.
• W2074156639 modified "2023-09-26" @default.
• W2074156639 title "The carboxyterminus of human c-myb protein stimulates activated transcription in<i>trans</i>" @default.
• W2074156639 cites W1533075742 @default.
• W2074156639 cites W1545319559 @default.
• W2074156639 cites W1547634286 @default.
• W2074156639 cites W1588283951 @default.
• W2074156639 cites W166699838 @default.
• W2074156639 cites W1735862314 @default.
• W2074156639 cites W1795937249 @default.
• W2074156639 cites W1813392716 @default.
• W2074156639 cites W1838891968 @default.
• W2074156639 cites W1860047937 @default.
• W2074156639 cites W1872695944 @default.
• W2074156639 cites W1943704911 @default.
• W2074156639 cites W1947494773 @default.
• W2074156639 cites W1972260692 @default.
• W2074156639 cites W1979344499 @default.
• W2074156639 cites W1979647722 @default.
• W2074156639 cites W1986473194 @default.
• W2074156639 cites W1988573337 @default.
• W2074156639 cites W2002357551 @default.
• W2074156639 cites W2006874407 @default.
• W2074156639 cites W2012170788 @default.
• W2074156639 cites W2025162213 @default.
• W2074156639 cites W2026728933 @default.
• W2074156639 cites W2028129834 @default.
• W2074156639 cites W2030156849 @default.
• W2074156639 cites W2037489737 @default.
• W2074156639 cites W2042157210 @default.
• W2074156639 cites W2042425655 @default.
• W2074156639 cites W2044865169 @default.
• W2074156639 cites W2045052763 @default.
• W2074156639 cites W2046837990 @default.
• W2074156639 cites W2046994642 @default.
• W2074156639 cites W2050766639 @default.
• W2074156639 cites W2051464339 @default.
• W2074156639 cites W2065553730 @default.
• W2074156639 cites W2066865170 @default.
• W2074156639 cites W2068964785 @default.
• W2074156639 cites W2075496313 @default.
• W2074156639 cites W2083591429 @default.
• W2074156639 cites W2084818621 @default.
• W2074156639 cites W2089099063 @default.
• W2074156639 cites W2089779712 @default.
• W2074156639 cites W2092781810 @default.
• W2074156639 cites W2094872845 @default.
• W2074156639 cites W2097794242 @default.
• W2074156639 cites W2101242267 @default.
• W2074156639 cites W2127523007 @default.
• W2074156639 cites W2133084943 @default.
• W2074156639 cites W2154471904 @default.
• W2074156639 cites W2170005346 @default.
• W2074156639 cites W2170136346 @default.
• W2074156639 cites W2244005360 @default.
• W2074156639 cites W2267572959 @default.
• W2074156639 cites W22944490 @default.
• W2074156639 cites W2398952020 @default.
• W2074156639 cites W2417917479 @default.
• W2074156639 cites W2433429187 @default.
• W2074156639 cites W2464625642 @default.
• W2074156639 cites W2471966040 @default.
• W2074156639 cites W4285719527 @default.
• W2074156639 cites W990608062 @default.
• W2074156639 doi "https://doi.org/10.1093/nar/22.13.2466" @default.
• W2074156639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/308197" @default.
• W2074156639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8041607" @default.
• W2074156639 hasPublicationYear "1994" @default.
• W2074156639 type Work @default.
• W2074156639 sameAs 2074156639 @default.
• W2074156639 citedByCount "22" @default.
• W2074156639 countsByYear W20741566392019 @default.
• W2074156639 countsByYear W20741566392021 @default.
• W2074156639 crossrefType "journal-article" @default.
• W2074156639 hasAuthorship W2074156639A5049872530 @default.
• W2074156639 hasAuthorship W2074156639A5071063397 @default.
• W2074156639 hasAuthorship W2074156639A5074422772 @default.
• W2074156639 hasAuthorship W2074156639A5090218748 @default.
• W2074156639 hasBestOaLocation W20741566391 @default.
• W2074156639 hasConcept C104317684 @default.
• W2074156639 hasConcept C1292079 @default.
• W2074156639 hasConcept C138885662 @default.
• W2074156639 hasConcept C153911025 @default.
• W2074156639 hasConcept C179926584 @default.
• W2074156639 hasConcept C41895202 @default.
• W2074156639 hasConcept C54355233 @default.
• W2074156639 hasConcept C62794011 @default.
• W2074156639 hasConcept C86339819 @default.
• W2074156639 hasConcept C86803240 @default.
• W2074156639 hasConcept C94966510 @default.
• W2074156639 hasConcept C95444343 @default.
• W2074156639 hasConceptScore W2074156639C104317684 @default.

• next