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- W2074157024 abstract "In small-cell lung cancer, the optimal combination of chemotherapy and radiotherapy is not clearly established. To assess the value of delayed thoracic radiotherapy, we performed a randomized clinical trial in 53 complete responder patients after eight courses of chemotherapy. Twenty-seven patients received a mean of 46.5 Gy-equivalent of radiotherapy and 26 patients received no treatment until relapse. No patient dropped out of the study. Median survival time from radiotherapy randomization was 316 days in the radiotherapy group and 496 days in the no radiotherapy group. No difference was observed in survival between the two groups (p=0.66, log-rank test) perhaps because of the small sample size. In fact, this delayed thoracic radiotherapy seemed to worsen the outcome of complete responders with small-cell lung cancer and should be avoided. In small-cell lung cancer, the optimal combination of chemotherapy and radiotherapy is not clearly established. To assess the value of delayed thoracic radiotherapy, we performed a randomized clinical trial in 53 complete responder patients after eight courses of chemotherapy. Twenty-seven patients received a mean of 46.5 Gy-equivalent of radiotherapy and 26 patients received no treatment until relapse. No patient dropped out of the study. Median survival time from radiotherapy randomization was 316 days in the radiotherapy group and 496 days in the no radiotherapy group. No difference was observed in survival between the two groups (p=0.66, log-rank test) perhaps because of the small sample size. In fact, this delayed thoracic radiotherapy seemed to worsen the outcome of complete responders with small-cell lung cancer and should be avoided. The Role of Routine Chest Radiotherapy in Small-Cell Lung Cancer: An Issue of Timing and StageCHESTVol. 104Issue 3PreviewA study by the British Medical Research Council conducted in the 1960s showed the superiority of chest radiotherapy over surgery in the treatment of small-cell lung cancer (SCLC). This study firmly established the importance of chest radiotherapy in the treatment of patients with early stages of this dread disease. Unfortunately, chest radiotherapy alone resulted in a median survival of less than 12 months, and fewer than 1 percent of patients survived 5 years. During the 1970s, combination chemotherapy supplanted chest radiotherapy as the cornerstone of therapy for SCLC patients because it improved both median and long-term survival compared with radiotherapy or surgery alone. Full-Text PDF" @default.
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- W2074157024 date "1993-09-01" @default.
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- W2074157024 title "A Randomized Trial of Delayed Thoracic Radiotherapy in Complete Responder Patients With Small-Cell Lung Cancer" @default.
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- W2074157024 doi "https://doi.org/10.1378/chest.104.3.726" @default.
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