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- W2074160967 abstract "Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial, venous or small-vessel thrombotic events, and recurrent miscarriages or fetal loss. APS diagnosis is based on the repeated detection of anti-phospholipid (PL) antibodies (Ab), typically associated with anti-β2 glycoprotein I (β2GPI)-Ab. Recent studies suggest that anti-β2GPI Ab activity involves a protein complex including β2GPI and annexin A2 (ANXA2). Anti-ANXA2 Ab recognizes this complex, and these Ab can effectively promote thrombosis by inhibiting plasmin generation, and by activating endothelial cells. Therefore, anti-ANXA2 Ab represent a new biomarker, which can be detected in up to 25% of APS patients. Moreover, anti-ANXA2 Ab have been detected, in thrombotic associated diseases including pre-eclampsia, in other autoimmune diseases, and in cancer." @default.
- W2074160967 created "2016-06-24" @default.
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- W2074160967 date "2015-02-01" @default.
- W2074160967 modified "2023-10-14" @default.
- W2074160967 title "Annexin A2 autoantibodies in thrombosis and autoimmune diseases" @default.
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- W2074160967 doi "https://doi.org/10.1016/j.thromres.2014.11.034" @default.
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- W2074160967 hasPublicationYear "2015" @default.
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