FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074163485> ?p ?o ?g. }

• W2074163485 endingPage "1297" @default.
• W2074163485 startingPage "1288" @default.
• W2074163485 abstract "Ribonucleoside diphosphate reductase (EC 1.17.4.1) (RR) is a potential target for antineoplastic agents due to its crucial role in DNA replication and repair. The expression and activity of RR subunits are highly regulated to maintain an optimal dNTP pool, which is required to maintain genetic fidelity. The human RR small subunit M2B (p53R2) is thought to contribute to DNA repair in response to DNA damage. However, it is not clear whether M2B is involved in providing dNTPs for DNA replication under physiological growth conditions. Serum starvation synchronized studies showed that a rapid increase of M2B was associated with cyclin E, which is responsible for regulation of G1/S-phase transition. A living cell sorting study that used KB cells in normal growth, further confirmed that M2B increased to maximum levels at the G1/S-phase transition, and decreased with DNA synthesis. Confocal studies revealed that M2B redistributed from the cytoplasm to the nucleus earlier than hRRM2 in response to DNA replication. Nuclear accumulation of M2B is associated with dynamic changes in dNTP at early periods of serum addition. By using M2B-shRNA expression vectors, inhibition of M2B may result in growth retardation in KB cells. We conclude that M2B may translocate from the cytoplasm into the nucleus and allow dNTPs to initiate DNA synthesis in KB cells under physiological conditions. Thus, our findings suggested that M2B might play an important role for initiating DNA replication of KB cells in normal growth." @default.
• W2074163485 created "2016-06-24" @default.
• W2074163485 creator A5003499358 @default.
• W2074163485 creator A5009104622 @default.
• W2074163485 creator A5031124433 @default.
• W2074163485 creator A5043900590 @default.
• W2074163485 creator A5048401428 @default.
• W2074163485 creator A5077562743 @default.
• W2074163485 creator A5081487015 @default.
• W2074163485 date "2005-11-01" @default.
• W2074163485 modified "2023-10-13" @default.
• W2074163485 title "The ribonucleotide reductase subunit M2B subcellular localization and functional importance for DNA replication in physiological growth of KB cells" @default.
• W2074163485 cites W1035654001 @default.
• W2074163485 cites W1503561348 @default.
• W2074163485 cites W1528443459 @default.
• W2074163485 cites W1536062643 @default.
• W2074163485 cites W1537111418 @default.
• W2074163485 cites W1572756764 @default.
• W2074163485 cites W1680634601 @default.
• W2074163485 cites W1963876890 @default.
• W2074163485 cites W1964764834 @default.
• W2074163485 cites W1967830103 @default.
• W2074163485 cites W1973802186 @default.
• W2074163485 cites W1975446306 @default.
• W2074163485 cites W1977368774 @default.
• W2074163485 cites W1981040381 @default.
• W2074163485 cites W1981784972 @default.
• W2074163485 cites W1981954689 @default.
• W2074163485 cites W2005278252 @default.
• W2074163485 cites W2009486080 @default.
• W2074163485 cites W2011442761 @default.
• W2074163485 cites W2027846898 @default.
• W2074163485 cites W2033971720 @default.
• W2074163485 cites W2035782088 @default.
• W2074163485 cites W2041309792 @default.
• W2074163485 cites W2042006572 @default.
• W2074163485 cites W2050225595 @default.
• W2074163485 cites W2050630298 @default.
• W2074163485 cites W2053374394 @default.
• W2074163485 cites W2058704920 @default.
• W2074163485 cites W2063222971 @default.
• W2074163485 cites W2075228155 @default.
• W2074163485 cites W2087913780 @default.
• W2074163485 cites W2126928834 @default.
• W2074163485 cites W2130386700 @default.
• W2074163485 cites W2154959891 @default.
• W2074163485 cites W2162031449 @default.
• W2074163485 cites W2170444924 @default.
• W2074163485 cites W2170473454 @default.
• W2074163485 cites W2254058835 @default.
• W2074163485 cites W2415175854 @default.
• W2074163485 cites W2769973653 @default.
• W2074163485 cites W4211020343 @default.
• W2074163485 cites W4248412843 @default.
• W2074163485 doi "https://doi.org/10.1016/j.bcp.2005.08.005" @default.
• W2074163485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16168962" @default.
• W2074163485 hasPublicationYear "2005" @default.
• W2074163485 type Work @default.
• W2074163485 sameAs 2074163485 @default.
• W2074163485 citedByCount "32" @default.
• W2074163485 countsByYear W20741634852012 @default.
• W2074163485 countsByYear W20741634852013 @default.
• W2074163485 countsByYear W20741634852014 @default.
• W2074163485 countsByYear W20741634852017 @default.
• W2074163485 countsByYear W20741634852022 @default.
• W2074163485 crossrefType "journal-article" @default.
• W2074163485 hasAuthorship W2074163485A5003499358 @default.
• W2074163485 hasAuthorship W2074163485A5009104622 @default.
• W2074163485 hasAuthorship W2074163485A5031124433 @default.
• W2074163485 hasAuthorship W2074163485A5043900590 @default.
• W2074163485 hasAuthorship W2074163485A5048401428 @default.
• W2074163485 hasAuthorship W2074163485A5077562743 @default.
• W2074163485 hasAuthorship W2074163485A5081487015 @default.
• W2074163485 hasConcept C104292427 @default.
• W2074163485 hasConcept C104317684 @default.
• W2074163485 hasConcept C104690221 @default.
• W2074163485 hasConcept C151158763 @default.
• W2074163485 hasConcept C153911025 @default.
• W2074163485 hasConcept C188036394 @default.
• W2074163485 hasConcept C4710235 @default.
• W2074163485 hasConcept C54355233 @default.
• W2074163485 hasConcept C552990157 @default.
• W2074163485 hasConcept C73573662 @default.
• W2074163485 hasConcept C86803240 @default.
• W2074163485 hasConcept C95444343 @default.
• W2074163485 hasConcept C98086919 @default.
• W2074163485 hasConceptScore W2074163485C104292427 @default.
• W2074163485 hasConceptScore W2074163485C104317684 @default.
• W2074163485 hasConceptScore W2074163485C104690221 @default.
• W2074163485 hasConceptScore W2074163485C151158763 @default.
• W2074163485 hasConceptScore W2074163485C153911025 @default.
• W2074163485 hasConceptScore W2074163485C188036394 @default.
• W2074163485 hasConceptScore W2074163485C4710235 @default.
• W2074163485 hasConceptScore W2074163485C54355233 @default.
• W2074163485 hasConceptScore W2074163485C552990157 @default.
• W2074163485 hasConceptScore W2074163485C73573662 @default.
• W2074163485 hasConceptScore W2074163485C86803240 @default.
• W2074163485 hasConceptScore W2074163485C95444343 @default.

• next