FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074163964> ?p ?o ?g. }

• W2074163964 endingPage "2536" @default.
• W2074163964 startingPage "2527" @default.
• W2074163964 abstract "Activation of MAP kinase leads to the activation of p53-dependent pathways, and vice-versa. Although the amount of p53 protein increases in response to MAP kinase-dependent signaling, the basis of this increase is not yet fully understood. We have isolated the mutant cell line AP14, defective in p53 expression, from human HT1080 fibrosarcoma cells, which have an activated ras allele. The expression of p53 mRNA and protein is approximately 10-fold lower in AP14 cells than in the parental cells. The high constitutive phosphorylation and activities of the MAP kinases ERK1 and ERK2 in HT1080 cells are greatly reduced in AP14 cells, although the levels of these proteins are unchanged, suggesting that the defect in the mutant cells affects the steady-state phosphorylation of ERK1 and ERK2. Overexpression of ERK2 in AP14 cells restored both MAP kinase activity and p53 expression, and incubation of the mutant cells with the phosphatase inhibitor orthovanadate resulted in strong coordinate elevation of MAP kinase activity and p53 expression. The levels of expression of the p53-regulated gene p21 parallel those of p53 throughout, showing that basal p21 expression depends on p53. The levels of p53 mRNA increased by 5-8-fold when activated ras was introduced into wild-type cells, and the levels of the p53 and p21 proteins decreased substantially in wild-type cells treated with the MEK inhibitor U0216. We conclude that MAP kinase-dependent pathways help to regulate p53 levels by regulating the expression of p53 mRNA." @default.
• W2074163964 created "2016-06-24" @default.
• W2074163964 creator A5005349109 @default.
• W2074163964 creator A5010965273 @default.
• W2074163964 creator A5012287162 @default.
• W2074163964 creator A5021264141 @default.
• W2074163964 creator A5021556196 @default.
• W2074163964 creator A5055322707 @default.
• W2074163964 creator A5057945296 @default.
• W2074163964 creator A5058117644 @default.
• W2074163964 creator A5069911187 @default.
• W2074163964 creator A5080998429 @default.
• W2074163964 date "2001-05-03" @default.
• W2074163964 modified "2023-10-18" @default.
• W2074163964 title "Regulation of p53 expression by the RAS-MAP kinase pathway" @default.
• W2074163964 cites W1494864623 @default.
• W2074163964 cites W1650797637 @default.
• W2074163964 cites W1925157258 @default.
• W2074163964 cites W1954929088 @default.
• W2074163964 cites W1966453709 @default.
• W2074163964 cites W1973199982 @default.
• W2074163964 cites W1976006348 @default.
• W2074163964 cites W1980472836 @default.
• W2074163964 cites W1986021037 @default.
• W2074163964 cites W1991494214 @default.
• W2074163964 cites W2006659499 @default.
• W2074163964 cites W2009556803 @default.
• W2074163964 cites W2012850212 @default.
• W2074163964 cites W2031725843 @default.
• W2074163964 cites W2057126981 @default.
• W2074163964 cites W2060810889 @default.
• W2074163964 cites W2068691401 @default.
• W2074163964 cites W2070023258 @default.
• W2074163964 cites W2072088194 @default.
• W2074163964 cites W2072243374 @default.
• W2074163964 cites W2080352303 @default.
• W2074163964 cites W2086262311 @default.
• W2074163964 cites W2087404852 @default.
• W2074163964 cites W2098097317 @default.
• W2074163964 cites W2099674213 @default.
• W2074163964 cites W2103565638 @default.
• W2074163964 cites W2119011939 @default.
• W2074163964 cites W2125547572 @default.
• W2074163964 cites W2144811267 @default.
• W2074163964 cites W2150710841 @default.
• W2074163964 cites W2151712105 @default.
• W2074163964 cites W2156299289 @default.
• W2074163964 cites W2158195967 @default.
• W2074163964 cites W2161709857 @default.
• W2074163964 cites W2324319461 @default.
• W2074163964 cites W4232460871 @default.
• W2074163964 cites W4250409924 @default.
• W2074163964 cites W4256403008 @default.
• W2074163964 doi "https://doi.org/10.1038/sj.onc.1204353" @default.
• W2074163964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11420662" @default.
• W2074163964 hasPublicationYear "2001" @default.
• W2074163964 type Work @default.
• W2074163964 sameAs 2074163964 @default.
• W2074163964 citedByCount "51" @default.
• W2074163964 countsByYear W20741639642013 @default.
• W2074163964 countsByYear W20741639642015 @default.
• W2074163964 countsByYear W20741639642017 @default.
• W2074163964 countsByYear W20741639642018 @default.
• W2074163964 countsByYear W20741639642020 @default.
• W2074163964 countsByYear W20741639642021 @default.
• W2074163964 countsByYear W20741639642022 @default.
• W2074163964 countsByYear W20741639642023 @default.
• W2074163964 crossrefType "journal-article" @default.
• W2074163964 hasAuthorship W2074163964A5005349109 @default.
• W2074163964 hasAuthorship W2074163964A5010965273 @default.
• W2074163964 hasAuthorship W2074163964A5012287162 @default.
• W2074163964 hasAuthorship W2074163964A5021264141 @default.
• W2074163964 hasAuthorship W2074163964A5021556196 @default.
• W2074163964 hasAuthorship W2074163964A5055322707 @default.
• W2074163964 hasAuthorship W2074163964A5057945296 @default.
• W2074163964 hasAuthorship W2074163964A5058117644 @default.
• W2074163964 hasAuthorship W2074163964A5069911187 @default.
• W2074163964 hasAuthorship W2074163964A5080998429 @default.
• W2074163964 hasBestOaLocation W20741639641 @default.
• W2074163964 hasConcept C132149769 @default.
• W2074163964 hasConcept C138227536 @default.
• W2074163964 hasConcept C153911025 @default.
• W2074163964 hasConcept C163035849 @default.
• W2074163964 hasConcept C184235292 @default.
• W2074163964 hasConcept C2776495794 @default.
• W2074163964 hasConcept C2777751087 @default.
• W2074163964 hasConcept C54355233 @default.
• W2074163964 hasConcept C62478195 @default.
• W2074163964 hasConcept C86803240 @default.
• W2074163964 hasConcept C90934575 @default.
• W2074163964 hasConcept C95444343 @default.
• W2074163964 hasConcept C97029542 @default.
• W2074163964 hasConceptScore W2074163964C132149769 @default.
• W2074163964 hasConceptScore W2074163964C138227536 @default.
• W2074163964 hasConceptScore W2074163964C153911025 @default.
• W2074163964 hasConceptScore W2074163964C163035849 @default.
• W2074163964 hasConceptScore W2074163964C184235292 @default.
• W2074163964 hasConceptScore W2074163964C2776495794 @default.

• next