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- W2074182012 abstract "Breast cancer progression is strongly linked to inflammatory processes, aggravating disease course. The impacts of the inflammatory cytokine TNF α on breast malignancy are not fully substantiated, and they may be affected by cooperativity between TNF α and other protumoral mediators. Here, we show that together with representatives of other important arms of the tumor microenvironment, estrogen (hormonal) and EGF (growth-supporting), TNF α potently induced metastasis-related properties and functions in luminal breast tumor cells, representing the most common type of breast cancer. Jointly, TNF α + Estrogen + EGF had a stronger effect on breast cancer cells than each element alone, leading to the following: (1) extensive cell spreading and formation of FAK/paxillin-enriched cellular protrusions; (2) elevated proportion of tumor cells coexpressing high levels of CD44 and β 1 and VLA6; (3) EMT and cell migration; (4) resistance to chemotherapy; (5) release of protumoral factors (CXCL8, CCL2, MMPs). Importantly, the tumor cells used in this study are known to be nonmetastatic under all conditions; nevertheless, they have acquired high metastasizing abilities in vivo in mice, following a brief stimulation by TNF α + Estrogen + EGF. These dramatic findings indicate that TNF α can turn into a strong prometastatic factor, suggesting a paradigm shift in which clinically approved inhibitors of TNF α would be applied in breast cancer therapy." @default.
- W2074182012 created "2016-06-24" @default.
- W2074182012 creator A5029299639 @default.
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- W2074182012 creator A5090109203 @default.
- W2074182012 date "2013-01-01" @default.
- W2074182012 modified "2023-10-17" @default.
- W2074182012 title "Progression of Luminal Breast Tumors Is Promoted by Ménage à Trois between the Inflammatory Cytokine TNF<i>α</i>and the Hormonal and Growth-Supporting Arms of the Tumor Microenvironment" @default.
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- W2074182012 doi "https://doi.org/10.1155/2013/720536" @default.
- W2074182012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3867893" @default.