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- W2074203977 abstract "The rearrangement and repair of DNA by homologous recombination often involves the creation of Holliday junctions, which must be cleaved by junction-specific endonucleases to yield recombinant duplex DNA products. Holliday junction resolving enzymes are a ubiquitous class of proteins with diverse structural and mechanistic characteristics. We have characterised an endonuclease (Hje) from the thermophilic crenarchaeote Sulfolobus solfataricus that exhibits a high degree of specificity for Holliday junctions via an apparently novel mechanism. Hje resolves four-way DNA junctions by the introduction of paired nicks in a reaction that is independent of the local nucleotide sequence, but is restricted solely to strands that are continuous in the stacked-X form of the junction. Three-way DNA junctions are cleaved only when the presence of a bulge in one strand allows the junction to stack in an analogous manner to four-way junctions. These properties differentiate Hje from all other known junction resolving enzymes." @default.
- W2074203977 created "2016-06-24" @default.
- W2074203977 creator A5057021821 @default.
- W2074203977 creator A5072685090 @default.
- W2074203977 date "2000-01-01" @default.
- W2074203977 modified "2023-10-14" @default.
- W2074203977 title "An archaeal holliday junction resolving enzyme from Sulfolobus solfataricus exhibits unique properties" @default.
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- W2074203977 doi "https://doi.org/10.1006/jmbi.1999.3363" @default.
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