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• W2074214095 abstract "Aims . The SLC2A9 gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion. The single nucleotide polymorphisms (SNPs) of SLC2A9 accounted for 5% variance of serum uric acid (UA). UA was identified as a risk factor for type 2 diabetes mellitus (DM). We investigated whether the SLC2A9 gene variations are associated with type 2 DM in Han Chinese. Methods . Three common SNPs of the SLC2A9 , rs1014290, rs2280205, and rs3733591, were genotyped in 1003 Han Chinese randomly selected from Kaohsiung, Taiwan. Results . The variant SNP rs1014290 is associated with decreased 0.12-fold risk of type 2 DM (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.002</mml:mn></mml:mrow></mml:math>). Per-copy increase in the minor C-allele results in 0.13 mmol/L (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.037</mml:mn></mml:mrow></mml:math>) and 10.03 μmol/L (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.016</mml:mn></mml:mrow></mml:math>) decrease in serum glucose and UA, respectively. Conclusions . The SNP rs1014290 within the SLC2A9 gene is associated with type 2 DM in Han Chinese." @default.
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• W2074214095 date "2011-01-01" @default.
• W2074214095 modified "2023-09-23" @default.
• W2074214095 title "The rs1014290 Polymorphism of the SLC2A9 Gene Is Associated with Type 2 Diabetes Mellitus in Han Chinese" @default.
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• W2074214095 doi "https://doi.org/10.1155/2011/527520" @default.
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