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• W2074214799 abstract "ObjectiveTo compare the effect on follicular growth and endocrine parameters of follicular phase administration of anastrozole to healthy, normoovulatory women in doses of 1 or 5 mg, respectively, with the conventional dosing regimen for ovulation induction with clomiphene citrate (CC).DesignRandomized, assessor-blinded, single-center, three-armed study.SettingUniversity-affiliated, tertiary referral center.Patient(s)Thirty-two, normoovulatory, normogonadotropic women.Intervention(s)Administration of anastrozole 1 mg (group A1), anastrozole 5 mg (group A5), or CC 50 mg (group CC50) from cycle days 3 to 7.Main Outcome Measure(s)Number of follicles ≥15 mm and ≥10 mm on the day of the endogenous LH surge.Result(s)The mean number of follicles ≥15 mm on the day of LH surge was 1.4 ± 0.5, 1.0 ± 0.4, and 0.8 ± 0.4 in groups CC50, A1, and A5, respectively, which was statistically significant. Furthermore, a statistically significant difference between groups was found for the size of the growing follicular cohort (follicles ≥10 mm) on cycle days 8 and 10 and on the day of LH surge. The area under the curve (adjusted for baseline values on cycle day 3 and time frame of assessment) of follicular phase E2 levels was significantly different among the groups that were compared (223.0 ± 97.5, 69.2 ± 40.0, and 83.4 ± 36.4 for groups CC50, A1, and A5, respectively).Conclusion(s)CC 50 mg exerts a stronger stimulatory effect on follicular growth compared with anastrozole in doses of 1 or 5 mg. Anastrozole administration results in lower follicular phase E2 levels. To compare the effect on follicular growth and endocrine parameters of follicular phase administration of anastrozole to healthy, normoovulatory women in doses of 1 or 5 mg, respectively, with the conventional dosing regimen for ovulation induction with clomiphene citrate (CC). Randomized, assessor-blinded, single-center, three-armed study. University-affiliated, tertiary referral center. Thirty-two, normoovulatory, normogonadotropic women. Administration of anastrozole 1 mg (group A1), anastrozole 5 mg (group A5), or CC 50 mg (group CC50) from cycle days 3 to 7. Number of follicles ≥15 mm and ≥10 mm on the day of the endogenous LH surge. The mean number of follicles ≥15 mm on the day of LH surge was 1.4 ± 0.5, 1.0 ± 0.4, and 0.8 ± 0.4 in groups CC50, A1, and A5, respectively, which was statistically significant. Furthermore, a statistically significant difference between groups was found for the size of the growing follicular cohort (follicles ≥10 mm) on cycle days 8 and 10 and on the day of LH surge. The area under the curve (adjusted for baseline values on cycle day 3 and time frame of assessment) of follicular phase E2 levels was significantly different among the groups that were compared (223.0 ± 97.5, 69.2 ± 40.0, and 83.4 ± 36.4 for groups CC50, A1, and A5, respectively). CC 50 mg exerts a stronger stimulatory effect on follicular growth compared with anastrozole in doses of 1 or 5 mg. Anastrozole administration results in lower follicular phase E2 levels." @default.
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• W2074214799 date "2009-05-01" @default.
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• W2074214799 title "Follicular and endocrine response to anastrozole versus clomiphene citrate administered in follicular phase to normoovulatory women: a randomized comparison" @default.
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• W2074214799 doi "https://doi.org/10.1016/j.fertnstert.2008.01.091" @default.
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