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- W2074228628 abstract "Strips of preprostatic urethra from immature male lambs (3–4 months old) were used to study α-adrenoceptor-mediated contractions in vitro. The rank order of potency of the agonists was noradrenaline = phenylephrine > adrenaline. B-HT 920 was ineffective and clonidine behaved as a weak partial agonist. The rank order of efficacy was found to be noradrenaline > phenylephrine > adrenaline. Prazosin (10−9−10−6M) and rauwolscine (10−6−10−4M) antagonized noradrenaline-induced contractions. The pA2 values were 7.89 and 5.38 for prazosin and rauwolscine, respectively. Phenoxybenzamine reduced the maximal response to noradrenaline and shifted the concentration-response curve to the right. The dissociation constant (KA) of noradrenaline was calculated to be 4.05 ± 0.21× 10−6 M and the occupancy-response plot for noradrenaline showed a linear relationship. It is concluded that α-adrenergic contraction of the preprostatic urethra from immature lambs are mediated by α1-adrenoceptors. It is also suggested that the lack of a receptor reserve may affect the degree of urethral constriction and could be related to hormonal status." @default.
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- W2074228628 date "1991-10-01" @default.
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- W2074228628 title "Characterization of α-adrenoceptors in the preprostatic urethra of sexually immature male lambs" @default.
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- W2074228628 doi "https://doi.org/10.1016/0014-2999(91)90722-3" @default.
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