Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074230807> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2074230807 endingPage "138" @default.
- W2074230807 startingPage "134" @default.
- W2074230807 abstract "Candesartan cilexetil is an angiotensin receptor antagonist widely used in the treatment of high blood pressure. This prodrug is metabolised into candesartan, which blocks the receptors AT1 for angiotensin II decreasing the blood pressure levels. During the development of a solid phase extraction procedure for the chromatographic determination of eight antihypertensive compounds, lack of linearity and reproducibility was observed only for candesartan cilexetil. Due to this fact, a stability study for this prodrug was performed. It showed that the lack of linearity and reproducibility was based on hydrolysis and transesterification processes which occurred during the drying step after elution with methanol into glass tubes. These phenomena could be reproduced artificially under basic conditions, which demonstrated the presence of basic residues in glass tubes. The study of this potential hydrolysis and transesterification reactions is very important to assure that labile drugs containing ester groups remain unaffected." @default.
- W2074230807 created "2016-06-24" @default.
- W2074230807 creator A5002588358 @default.
- W2074230807 creator A5021946841 @default.
- W2074230807 creator A5050368060 @default.
- W2074230807 creator A5053111500 @default.
- W2074230807 date "2007-08-01" @default.
- W2074230807 modified "2023-10-16" @default.
- W2074230807 title "Hydrolysis and transesterification reactions of candesartan cilexetil observed during the solid phase extraction procedure" @default.
- W2074230807 cites W1967305865 @default.
- W2074230807 cites W1980317106 @default.
- W2074230807 cites W1991354192 @default.
- W2074230807 cites W1999307269 @default.
- W2074230807 cites W2012927589 @default.
- W2074230807 cites W2024557497 @default.
- W2074230807 cites W2064899744 @default.
- W2074230807 cites W2153706144 @default.
- W2074230807 doi "https://doi.org/10.1016/j.jchromb.2007.04.009" @default.
- W2074230807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17478126" @default.
- W2074230807 hasPublicationYear "2007" @default.
- W2074230807 type Work @default.
- W2074230807 sameAs 2074230807 @default.
- W2074230807 citedByCount "28" @default.
- W2074230807 countsByYear W20742308072012 @default.
- W2074230807 countsByYear W20742308072013 @default.
- W2074230807 countsByYear W20742308072014 @default.
- W2074230807 countsByYear W20742308072015 @default.
- W2074230807 countsByYear W20742308072016 @default.
- W2074230807 countsByYear W20742308072018 @default.
- W2074230807 countsByYear W20742308072019 @default.
- W2074230807 countsByYear W20742308072020 @default.
- W2074230807 countsByYear W20742308072021 @default.
- W2074230807 crossrefType "journal-article" @default.
- W2074230807 hasAuthorship W2074230807A5002588358 @default.
- W2074230807 hasAuthorship W2074230807A5021946841 @default.
- W2074230807 hasAuthorship W2074230807A5050368060 @default.
- W2074230807 hasAuthorship W2074230807A5053111500 @default.
- W2074230807 hasConcept C108215921 @default.
- W2074230807 hasConcept C123915805 @default.
- W2074230807 hasConcept C170493617 @default.
- W2074230807 hasConcept C178790620 @default.
- W2074230807 hasConcept C185592680 @default.
- W2074230807 hasConcept C2777241282 @default.
- W2074230807 hasConcept C2779607525 @default.
- W2074230807 hasConcept C2780036600 @default.
- W2074230807 hasConcept C2908929049 @default.
- W2074230807 hasConcept C43617362 @default.
- W2074230807 hasConcept C4725764 @default.
- W2074230807 hasConcept C55493867 @default.
- W2074230807 hasConcept C81426234 @default.
- W2074230807 hasConcept C94412978 @default.
- W2074230807 hasConceptScore W2074230807C108215921 @default.
- W2074230807 hasConceptScore W2074230807C123915805 @default.
- W2074230807 hasConceptScore W2074230807C170493617 @default.
- W2074230807 hasConceptScore W2074230807C178790620 @default.
- W2074230807 hasConceptScore W2074230807C185592680 @default.
- W2074230807 hasConceptScore W2074230807C2777241282 @default.
- W2074230807 hasConceptScore W2074230807C2779607525 @default.
- W2074230807 hasConceptScore W2074230807C2780036600 @default.
- W2074230807 hasConceptScore W2074230807C2908929049 @default.
- W2074230807 hasConceptScore W2074230807C43617362 @default.
- W2074230807 hasConceptScore W2074230807C4725764 @default.
- W2074230807 hasConceptScore W2074230807C55493867 @default.
- W2074230807 hasConceptScore W2074230807C81426234 @default.
- W2074230807 hasConceptScore W2074230807C94412978 @default.
- W2074230807 hasIssue "2" @default.
- W2074230807 hasLocation W20742308071 @default.
- W2074230807 hasLocation W20742308072 @default.
- W2074230807 hasOpenAccess W2074230807 @default.
- W2074230807 hasPrimaryLocation W20742308071 @default.
- W2074230807 hasRelatedWork W1516285353 @default.
- W2074230807 hasRelatedWork W2006698999 @default.
- W2074230807 hasRelatedWork W2015929478 @default.
- W2074230807 hasRelatedWork W2085405463 @default.
- W2074230807 hasRelatedWork W2095227265 @default.
- W2074230807 hasRelatedWork W2109896298 @default.
- W2074230807 hasRelatedWork W2169111359 @default.
- W2074230807 hasRelatedWork W2190466816 @default.
- W2074230807 hasRelatedWork W2326355350 @default.
- W2074230807 hasRelatedWork W2414490559 @default.
- W2074230807 hasVolume "855" @default.
- W2074230807 isParatext "false" @default.
- W2074230807 isRetracted "false" @default.
- W2074230807 magId "2074230807" @default.
- W2074230807 workType "article" @default.