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- W2074236438 abstract "BackgroundAlpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune modulatory functions including the ability to inhibit caspases. Its clinical availability for infusion suggests that A1AT therapy might modulate caspase related inflammation. Here we tested the ability of A1AT to modulate caspase-1 function in human mononuclear phagocytes." @default.
- W2074236438 created "2016-06-24" @default.
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- W2074236438 date "2015-02-06" @default.
- W2074236438 modified "2023-10-14" @default.
- W2074236438 title "Alpha 1-Antitrypsin Does Not Inhibit Human Monocyte Caspase-1" @default.
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- W2074236438 doi "https://doi.org/10.1371/journal.pone.0117330" @default.
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