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• W2074243016 abstract "Cesium-134 tagged simulants with varying in vitro nuclide solubilities were analyzed with respect to absorbabilities of the 134Cs by the gastrointestinal tract of cotton rats (Sigmodon hispidus). Analysis of fecal material showed a rapid increase in radioactivity until the 42nd hr postadministration. Complete passage of the particulate matter was assumed to have occurred by the 66th hr. The elimination coefficients (lambdab) and biological half lives (Tb) of the 134Cs absorbed from the various simulants were: (1) 0.76%/hr, 3.79 days; (2) 1.16%/hr, 2.50 days; (3) 1.46%/hr, 1.98 days. The second experimental phase was to establish uptake rates and equilibrium levels for 134Cs in laboratory-born and wild-trapped cotton rats under chronic ingestion conditions, using 134Cs tagged lettuce as simulated contaminated vegetation, and to determine retention curves for 134Cs following termination of the chronic ingestion regimen. The 134Cs uptake for both groups appeared to be a multicomponent curve. Equations for uptake in the first component, from hour 16 to hour 208, were as follows: wild trapped: Y = 0.7727 × 10-2X0.5614 laboratory born: Y = 0.7746 × 10-2X0.5354 The second component began at hour 208 and continued until hour 544: wild trapped: Y = 0.4039 × 10-2X0.3448 laboratory born: Y = 0.4327 × 10-2X0.3278 After the 544th hr the rate increase was so slight that it was considered to be zero. While the rate increase of both groups was not different, the amount of 134Cs absorbed by the wild-trapped and laboratory-born groups showed a significant difference by the 64th hr. Retention curves, using the equilibrium levels as 100% incorporated 134Cs, broke down into two components. The first component (day 1 through 7), considered to be representative of systems such as the liver and intestinal tract, gave retention equations and biological half lives of laboratory born: Y = 92.8e−0.1332X, Tb = 5.20 days wild trapped: Y = 100.8e-0.lll6X, Tb = 6.21 days The second component (days 8 through 35) is believed to be indicative of the longer compartments, such as muscle, and is represented by: laboratory born: Y = 61.7e−0.0853X, Tb = 8.12 days wild trapped: Y = 79.0e−0.0827X, Tb = 8,38 days Serial sacrifices were made during both the uptake and excretion phases of the experiment, and eight tissues were analyzed for 134Cs. Accumulation and loss of 134Cs was slowest in muscle. It appears that the type of material ingested and the method of ingestion, acute (simulant particles) vs. chronic (vegetation), influenced the metabolic kinetics of 134Cs in cotton rats under laboratory conditions. Presumably, the cesium Ta was shorter in animals receiving a single dose of simulant because less cesium was incorporated in systemic compartments with slow uptake and long retention times." @default.
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• W2074243016 title "Uptake and Excretion of 134Cs from Fallout Simulant and Vegetation by Cotton Rats" @default.
• W2074243016 doi "https://doi.org/10.1097/00004032-196908000-00009" @default.
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