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- W2074244564 abstract "Background . Erythropoietin (EPO) is a neuroprotective agent utilized in stroke patients. This pilot study represents the first randomized trial of EPO in traumatic brain injury (TBI) patients. Methods . Adult, blunt trauma patients with evidence of TBI were randomized to EPO or placebo within 6 hours of injury. Baseline and daily serum S-100B and Neuron Specific Enolase (NSE) levels were measured. Results . TBI was worse in the EPO (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>11</mml:mn></mml:math>) group compared to placebo patients (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>5</mml:mn></mml:math>). The use of EPO did not impact NSE (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.89</mml:mn></mml:math>) or S100 B (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.53</mml:mn></mml:math>) levels compared to placebo. Conclusions . At the dose used, EPO did not reduce neuronal cell death compared to placebo; however, TBI severity was worse in the EPO group while levels of NSE and S100-B were similar to the less injured placebo group making it difficult to rule out a treatment effect. A larger, balanced study is necessary to confirm a potential treatment effect." @default.
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- W2074244564 date "2010-01-01" @default.
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- W2074244564 title "Safety and Efficacy of Erythropoietin in Traumatic Brain Injury Patients: A Pilot Randomized Trial" @default.
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- W2074244564 doi "https://doi.org/10.1155/2010/209848" @default.
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