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• W2074247685 abstract "The mammalian APOBEC3 family of cytidine deaminases includes several members that possess potent antiretroviral activity. Human APOBEC3F and APOBEC3G are specifically incorporated into human immunodeficiency virus type 1 (HIV-1) progeny virions in the absence of virion infectivity factor (Vif), where they deaminate deoxycytidine to deoxyuridine on the minus strand of nascent reverse transcripts. Editing of the HIV-1 cDNA leads to its degradation or to G to A hypermutation of the integrated provirus [1Sheehy A.M. Gaddis N.C. Choi J.D. Malim M.H. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.Nature. 2002; 418: 646-650Crossref PubMed Scopus (1835) Google Scholar, 2Mangeat B. Turelli P. Caron G. Friedli M. Perrin L. Trono D. Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.Nature. 2003; 424: 99-103Crossref PubMed Scopus (1201) Google Scholar, 3Zhang H. Yang B. Pomerantz R.J. Zhang C. Arunachalam S.C. Gao L. The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.Nature. 2003; 424: 94-98Crossref PubMed Scopus (897) Google Scholar, 4Harris R.S. Bishop K.N. Sheehy A.M. Craig H.M. Petersen-Mahrt S.K. Watt I.N. Neuberger M.S. Malim M.H. DNA deamination mediates innate immunity to retroviral infection.Cell. 2003; 113: 803-809Abstract Full Text Full Text PDF PubMed Scopus (1101) Google Scholar, 5Mariani R. Chen D. Schrofelbauer B. Navarro F. Konig R. Bollman B. Munk C. Nymark-McMahon H. Landau N.R. Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.Cell. 2003; 114: 21-31Abstract Full Text Full Text PDF PubMed Scopus (714) Google Scholar, 6Wiegand H.L. Doehle B.P. Bogerd H.P. Cullen B.R. A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins.EMBO J. 2004; 23: 2451-2458Crossref PubMed Scopus (403) Google Scholar, 7Bishop K.N. Holmes R.K. Sheehy A.M. Davidson N.O. Cho S.J. Malim M.H. Cytidine deamination of retroviral DNA by diverse APOBEC proteins.Curr. Biol. 2004; 14: 1392-1396Abstract Full Text Full Text PDF PubMed Scopus (509) Google Scholar, 8Zheng Y.H. Irwin D. Kurosu T. Tokunaga K. Sata T. Peterlin B.M. Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication.J. Virol. 2004; 78: 6073-6076Crossref PubMed Scopus (387) Google Scholar]. Here, we show that APOBEC3 proteins also restrict the activity of a distantly related long terminal repeat (LTR) retrotransposon. When expressed in the yeast Saccharomyces cerevisiae, human APOBEC3C, APOBEC3F, or APOBEC3G or mouse APOBEC3 potently inhibit replication of the Ty1 LTR retrotransposon. APOBEC3G interacts with Ty1 Gag and is packaged into Ty1 virus-like particles (VLPs) by a mechanism that closely resembles the one it uses to enter HIV-1 virions. Expression of APOBEC3G results in a reduced level of Ty1 cDNA integration and G to A editing of integrated Ty1 cDNA. Our findings indicate that APOBEC3G restricts Ty1 and HIV-1 by similar mechanisms and suggest that the APOBEC3 proteins target a substantially broader spectrum of retroelements than previously appreciated." @default.
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• W2074247685 date "2005-04-01" @default.
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• W2074247685 title "Inhibition of a Yeast LTR Retrotransposon by Human APOBEC3 Cytidine Deaminases" @default.
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• W2074247685 doi "https://doi.org/10.1016/j.cub.2005.02.051" @default.
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