FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074250255> ?p ?o ?g. }

• W2074250255 endingPage "235" @default.
• W2074250255 startingPage "222" @default.
• W2074250255 abstract "In young adult guinea pigs, the effects of unilateral ossicle removal and cochlear ablation were determined on transmitter release from glutamatergic presynaptic endings and glutamate inactivation via uptake. (i) D-[3H]Aspartate release and uptake were measured in subdivisions of the cochlear nucleus (CN) and in nuclei of the superior olive (SOC) and auditory midbrain (MB) up to 145 days after placing the lesions. Activities were compared to those from age-matched unlesioned controls. Fiber degeneration was visualized histologically. (ii) In the ipsilateral CN, changes in release and uptake were governed by the type of lesion. Ossicle removal produced sparse pruning of fibers only after 112 days and decreased release and uptake at 145 days, consistent with regulatory weakening of excitatory glutamatergic transmission. Cochlear ablation deafferented the CN, producing deficient release and uptake at 2 days and abundant fiber degeneration at 7 days. Subsequently, the residual release and uptake increased in magnitude, consistent with strengthening of excitatory glutamatergic transmission. (iii) In the contralateral CN, after either lesion, changes in release and uptake usually matched those in the ipsilateral CN. Thus, the auditory pathway associated with the lesioned ear probably provided cues for the regulation of synaptic strength in the contralateral CN. (iv) Both lesions increased release in the SOC and MB, and uptake in the SOC, consistent with strengthening of excitatory glutamatergic transmission. Sparse fiber degeneration, suggesting axonal pruning, appeared in the SOC and MB after cochlear ablation. (v) The strengthening of excitatory glutamatergic transmission may facilitate and maintain symptoms such as loudness recruitment and tinnitus which often accompany hearing loss." @default.
• W2074250255 created "2016-06-24" @default.
• W2074250255 creator A5031476924 @default.
• W2074250255 creator A5040613079 @default.
• W2074250255 creator A5052535392 @default.
• W2074250255 date "1997-11-01" @default.
• W2074250255 modified "2023-10-05" @default.
• W2074250255 title "Regulation ofd-Aspartate Release and Uptake in Adult Brain Stem Auditory Nuclei after Unilateral Middle Ear Ossicle Removal and Cochlear Ablation" @default.
• W2074250255 cites W1599165949 @default.
• W2074250255 cites W1778293074 @default.
• W2074250255 cites W1937675039 @default.
• W2074250255 cites W1968430807 @default.
• W2074250255 cites W1978159855 @default.
• W2074250255 cites W1979435345 @default.
• W2074250255 cites W1980829665 @default.
• W2074250255 cites W1984985902 @default.
• W2074250255 cites W1988090532 @default.
• W2074250255 cites W1992216070 @default.
• W2074250255 cites W1992295484 @default.
• W2074250255 cites W1994303136 @default.
• W2074250255 cites W1997653797 @default.
• W2074250255 cites W1998474999 @default.
• W2074250255 cites W1999029921 @default.
• W2074250255 cites W2000638401 @default.
• W2074250255 cites W2002273804 @default.
• W2074250255 cites W2002602712 @default.
• W2074250255 cites W2007067661 @default.
• W2074250255 cites W2010620346 @default.
• W2074250255 cites W2011420265 @default.
• W2074250255 cites W2012516129 @default.
• W2074250255 cites W2022198362 @default.
• W2074250255 cites W2024798559 @default.
• W2074250255 cites W2033500343 @default.
• W2074250255 cites W2034646869 @default.
• W2074250255 cites W2037552642 @default.
• W2074250255 cites W2038550437 @default.
• W2074250255 cites W2039663796 @default.
• W2074250255 cites W2039932521 @default.
• W2074250255 cites W2044230364 @default.
• W2074250255 cites W2044937656 @default.
• W2074250255 cites W2046450850 @default.
• W2074250255 cites W2048818224 @default.
• W2074250255 cites W2050078953 @default.
• W2074250255 cites W2053552469 @default.
• W2074250255 cites W2055917188 @default.
• W2074250255 cites W2056630997 @default.
• W2074250255 cites W2057275874 @default.
• W2074250255 cites W2057570924 @default.
• W2074250255 cites W2064031568 @default.
• W2074250255 cites W2064268558 @default.
• W2074250255 cites W2068025345 @default.
• W2074250255 cites W2071627906 @default.
• W2074250255 cites W2074174153 @default.
• W2074250255 cites W2076679902 @default.
• W2074250255 cites W2080466389 @default.
• W2074250255 cites W2081201335 @default.
• W2074250255 cites W2085445754 @default.
• W2074250255 cites W2089616345 @default.
• W2074250255 cites W2090056181 @default.
• W2074250255 cites W2091452463 @default.
• W2074250255 cites W2124932839 @default.
• W2074250255 cites W2143935196 @default.
• W2074250255 cites W2148032282 @default.
• W2074250255 cites W2164843997 @default.
• W2074250255 cites W2166231995 @default.
• W2074250255 cites W2169062120 @default.
• W2074250255 cites W2169191420 @default.
• W2074250255 cites W4235320318 @default.
• W2074250255 doi "https://doi.org/10.1006/exnr.1997.6641" @default.
• W2074250255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9398464" @default.
• W2074250255 hasPublicationYear "1997" @default.
• W2074250255 type Work @default.
• W2074250255 sameAs 2074250255 @default.
• W2074250255 citedByCount "107" @default.
• W2074250255 countsByYear W20742502552012 @default.
• W2074250255 countsByYear W20742502552013 @default.
• W2074250255 countsByYear W20742502552014 @default.
• W2074250255 countsByYear W20742502552015 @default.
• W2074250255 countsByYear W20742502552016 @default.
• W2074250255 countsByYear W20742502552017 @default.
• W2074250255 countsByYear W20742502552018 @default.
• W2074250255 countsByYear W20742502552019 @default.
• W2074250255 countsByYear W20742502552020 @default.
• W2074250255 countsByYear W20742502552022 @default.
• W2074250255 crossrefType "journal-article" @default.
• W2074250255 hasAuthorship W2074250255A5031476924 @default.
• W2074250255 hasAuthorship W2074250255A5040613079 @default.
• W2074250255 hasAuthorship W2074250255A5052535392 @default.
• W2074250255 hasConcept C105702510 @default.
• W2074250255 hasConcept C112592302 @default.
• W2074250255 hasConcept C126322002 @default.
• W2074250255 hasConcept C142724271 @default.
• W2074250255 hasConcept C169760540 @default.
• W2074250255 hasConcept C170493617 @default.
• W2074250255 hasConcept C17077164 @default.
• W2074250255 hasConcept C2775980177 @default.
• W2074250255 hasConcept C2777662796 @default.
• W2074250255 hasConcept C2779091101 @default.

• next