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- W2074257588 abstract "One hundred and sixty-eight female Sprague-Dawley rats were divided among 4 groups (42 rats/group) and were irradiated with 400 rad [137Cs] γ rays to the whole body when 59 days old. The estrogen antagonist tamoxifen was injected s.c. daily from 29–89 days of age (Series 1) or from 89–149 days of age (Series2), prior to the onset of palpable mammary tumors. Two groups of rats were injected with the diluent and served as controls. All rats were palpated bi-weekly for mammary tumors and killed 37 weeks after γ-irradiation. The number of mammary carcinomas which developed in each group and their significance levels were: series 1, controls, 31; tamoxifen treated, 11, P < 0.01; series 2, controls, 33; tamoxifen treated, 17, P < 0.01. Tamoxifen treatment did not significantly influence the incidence of benign mammary tumors (fibroadenomas) nor the rate of body weight gain. Thus, the effective use of an estrogen antagonist for the prophylaxis of radiogenic mammary carcinomas has been demonstrated in this study." @default.
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- W2074257588 title "Effect of an estrogen antagonist (tamoxifen) on the initiation and progression of γ-irradiation-induced mammary tumors in female Sprague-Dawley rats" @default.
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- W2074257588 doi "https://doi.org/10.1016/0014-2964(81)90004-9" @default.
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