FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074272859> ?p ?o ?g. }

• W2074272859 endingPage "106" @default.
• W2074272859 startingPage "98" @default.
• W2074272859 abstract "Intensive medical care of women with diabetes has reduced their risks of bearing infants with congenital anomalies. To assess the preventive potential of preconceptional care, the data of a population-based study of cardiovascular malformations (CVM) were analyzed to determine the morphogenetic specificity of maternal diabetes risks, the morbidity and mortality of the infants, and maternal characteristics that might affect these risks.The Baltimore-Washington Infant Study was a case-control study (1981-1989) that included all live born infants with confirmed CVM; control infants were a representative sample of the birth cohort. A questionnaire administered in home visits recorded parental information on social, medical, occupational, and environmental factors. For these analyses of preconceptional diabetes risks, the case group excluded chromosomal and mendelian disorders and was divided into 3 developmental categories and 12 diagnostic groups.Preconceptional maternal diabetes was strongly associated with CVM of early embryonic origin (odds ratio [OR] = 4.7, 95% confidence interval [CI] 2.8-7.9) and with cardiomyopathy (OR = 15.1, 95% CI 5.5-41.3), but not with obstructive and shunting defects (OR = 1.4, 95% CI 0.7-3.0). There was heterogeneity within these developmental categories: among laterality defects, diabetes was associated only with cardiovisceral and atrioventricular discordance (OR = 10.0, 95% CI 3.7-27.0); among outflow tract anomalies, the risk was strongly associated with normally related great arteries (OR = 6.6, 95% CI 3.2-13.3) but not with simple transpositions; and among atrioventricular septal defects, diabetes was associated with the complete but not with the partial forms (OR = 22.8, 95% CI 7.4-70.5). The association in early CVM was strongest among infants with multisystem, predominantly VACTERL, anomalies. All-cause mortality of infants with CVM was 39% among those with diabetic mothers and 17.8% in those with nondiabetic mothers. Deceased infants of diabetic mothers were also more likely to have extracardiac anomalies (P = 0.041), to be born prematurely (P = 0.007), and to have low birth weight (P = 0.011). Multivariate analyses of maternal factors revealed no significant confounders of the diabetes associations.The evidence of diabetes-induced major cardiac defects is of urgent clinical significance. The effectiveness of early preconceptional care in the prevention of congenital anomalies has been demonstrated repeatedly." @default.
• W2074272859 created "2016-06-24" @default.
• W2074272859 creator A5025029404 @default.
• W2074272859 creator A5033735039 @default.
• W2074272859 creator A5091893726 @default.
• W2074272859 date "2001-01-01" @default.
• W2074272859 modified "2023-10-14" @default.
• W2074272859 title "Maternal diabetes: An independent risk factor for major cardiovascular malformations with increased mortality of affected infants" @default.
• W2074272859 cites W1589901998 @default.
• W2074272859 cites W1940557805 @default.
• W2074272859 cites W1951862796 @default.
• W2074272859 cites W1978449965 @default.
• W2074272859 cites W1984955075 @default.
• W2074272859 cites W1985479666 @default.
• W2074272859 cites W1995094540 @default.
• W2074272859 cites W1999005444 @default.
• W2074272859 cites W2006110486 @default.
• W2074272859 cites W2007132078 @default.
• W2074272859 cites W2009426744 @default.
• W2074272859 cites W2013473278 @default.
• W2074272859 cites W2026167593 @default.
• W2074272859 cites W2052751274 @default.
• W2074272859 cites W2058139490 @default.
• W2074272859 cites W2063726391 @default.
• W2074272859 cites W2066371063 @default.
• W2074272859 cites W2068232323 @default.
• W2074272859 cites W2085972216 @default.
• W2074272859 cites W2086168740 @default.
• W2074272859 cites W2088398066 @default.
• W2074272859 cites W2093962592 @default.
• W2074272859 cites W2101379470 @default.
• W2074272859 cites W2103165244 @default.
• W2074272859 cites W2128110348 @default.
• W2074272859 cites W2140630674 @default.
• W2074272859 cites W2147301551 @default.
• W2074272859 cites W2162758480 @default.
• W2074272859 cites W2170181331 @default.
• W2074272859 cites W2324588265 @default.
• W2074272859 cites W2395736372 @default.
• W2074272859 cites W4323874430 @default.
• W2074272859 doi "https://doi.org/10.1002/tera.1051" @default.
• W2074272859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11460261" @default.
• W2074272859 hasPublicationYear "2001" @default.
• W2074272859 type Work @default.
• W2074272859 sameAs 2074272859 @default.
• W2074272859 citedByCount "192" @default.
• W2074272859 countsByYear W20742728592012 @default.
• W2074272859 countsByYear W20742728592013 @default.
• W2074272859 countsByYear W20742728592014 @default.
• W2074272859 countsByYear W20742728592015 @default.
• W2074272859 countsByYear W20742728592016 @default.
• W2074272859 countsByYear W20742728592017 @default.
• W2074272859 countsByYear W20742728592018 @default.
• W2074272859 countsByYear W20742728592019 @default.
• W2074272859 countsByYear W20742728592020 @default.
• W2074272859 countsByYear W20742728592021 @default.
• W2074272859 countsByYear W20742728592022 @default.
• W2074272859 countsByYear W20742728592023 @default.
• W2074272859 crossrefType "journal-article" @default.
• W2074272859 hasAuthorship W2074272859A5025029404 @default.
• W2074272859 hasAuthorship W2074272859A5033735039 @default.
• W2074272859 hasAuthorship W2074272859A5091893726 @default.
• W2074272859 hasConcept C126322002 @default.
• W2074272859 hasConcept C131872663 @default.
• W2074272859 hasConcept C134018914 @default.
• W2074272859 hasConcept C156957248 @default.
• W2074272859 hasConcept C187212893 @default.
• W2074272859 hasConcept C2779234561 @default.
• W2074272859 hasConcept C2908647359 @default.
• W2074272859 hasConcept C44249647 @default.
• W2074272859 hasConcept C50440223 @default.
• W2074272859 hasConcept C54355233 @default.
• W2074272859 hasConcept C555293320 @default.
• W2074272859 hasConcept C71924100 @default.
• W2074272859 hasConcept C86803240 @default.
• W2074272859 hasConcept C99454951 @default.
• W2074272859 hasConceptScore W2074272859C126322002 @default.
• W2074272859 hasConceptScore W2074272859C131872663 @default.
• W2074272859 hasConceptScore W2074272859C134018914 @default.
• W2074272859 hasConceptScore W2074272859C156957248 @default.
• W2074272859 hasConceptScore W2074272859C187212893 @default.
• W2074272859 hasConceptScore W2074272859C2779234561 @default.
• W2074272859 hasConceptScore W2074272859C2908647359 @default.
• W2074272859 hasConceptScore W2074272859C44249647 @default.
• W2074272859 hasConceptScore W2074272859C50440223 @default.
• W2074272859 hasConceptScore W2074272859C54355233 @default.
• W2074272859 hasConceptScore W2074272859C555293320 @default.
• W2074272859 hasConceptScore W2074272859C71924100 @default.
• W2074272859 hasConceptScore W2074272859C86803240 @default.
• W2074272859 hasConceptScore W2074272859C99454951 @default.
• W2074272859 hasIssue "2" @default.
• W2074272859 hasLocation W20742728591 @default.
• W2074272859 hasLocation W20742728592 @default.
• W2074272859 hasOpenAccess W2074272859 @default.
• W2074272859 hasPrimaryLocation W20742728591 @default.
• W2074272859 hasRelatedWork W1843463370 @default.
• W2074272859 hasRelatedWork W1982619745 @default.
• W2074272859 hasRelatedWork W2002325000 @default.

• next