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- W2074276758 abstract "Gene and oligonucleotide therapy are emerging as clinically viable therapeutic regimens for genetic, neoplastic, and infectious diseases. Approaches include insertion of human genes in viral vectors including recombinant retrovirus, adenovirus, adeno-associated virus, and herpes simplex virus-1, or recombinant bacterial plasmids. Viral vectors transfect cells directly; plasmid DNA is delivered with the help of cationic liposomes (lipofection), polylysine conjugates, gramicidin S, artificial viral envelopes or other such intracellular carriers. Major areas of interest include replacement of the cystic fibrosis transmembrane regulator gene and the alpha 1-antitrypsin gene; arrest of human immunodeficiency virus infection; and reversal of tumorigenicity and cancer immunization, among others. Oligonucleotide therapy is principally focusing on the same areas, although the approach is to halt DNA transcription or messenger RNA translation with code-blocking triple-helix-forming or antisense oligomers. Contributions from the pharmaceutical sciences are expected in pharmaceutical chemistry, drug delivery systems design, analytical chemistry, and biopharmaceutics." @default.
- W2074276758 created "2016-06-24" @default.
- W2074276758 creator A5053998349 @default.
- W2074276758 date "1994-01-01" @default.
- W2074276758 modified "2023-09-25" @default.
- W2074276758 title "The new frontier: gene and oligonucleotide therapy" @default.
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- W2074276758 cites W1534317533 @default.
- W2074276758 cites W1544265936 @default.
- W2074276758 cites W1554786089 @default.
- W2074276758 cites W1950013291 @default.
- W2074276758 cites W1965319333 @default.
- W2074276758 cites W1965751380 @default.
- W2074276758 cites W1966434125 @default.
- W2074276758 cites W1967159817 @default.
- W2074276758 cites W1969378476 @default.
- W2074276758 cites W1980401440 @default.
- W2074276758 cites W1981710211 @default.
- W2074276758 cites W1982224993 @default.
- W2074276758 cites W1983643599 @default.
- W2074276758 cites W1988096916 @default.
- W2074276758 cites W1990207135 @default.
- W2074276758 cites W1991037396 @default.
- W2074276758 cites W1993038891 @default.
- W2074276758 cites W1995998373 @default.
- W2074276758 cites W2000707502 @default.
- W2074276758 cites W2001332902 @default.
- W2074276758 cites W2002323372 @default.
- W2074276758 cites W2005170146 @default.
- W2074276758 cites W2005920135 @default.
- W2074276758 cites W2007335266 @default.
- W2074276758 cites W2009364394 @default.
- W2074276758 cites W2012522150 @default.
- W2074276758 cites W2013359336 @default.
- W2074276758 cites W2013603367 @default.
- W2074276758 cites W2014495927 @default.
- W2074276758 cites W2015881103 @default.
- W2074276758 cites W2018609257 @default.
- W2074276758 cites W2019927412 @default.
- W2074276758 cites W2022209895 @default.
- W2074276758 cites W2024913717 @default.
- W2074276758 cites W2026922744 @default.
- W2074276758 cites W2031860235 @default.
- W2074276758 cites W2033222891 @default.
- W2074276758 cites W2034642422 @default.
- W2074276758 cites W2044910913 @default.
- W2074276758 cites W2049071996 @default.
- W2074276758 cites W2053374868 @default.
- W2074276758 cites W2055750024 @default.
- W2074276758 cites W2056493766 @default.
- W2074276758 cites W2058253654 @default.
- W2074276758 cites W2059688446 @default.
- W2074276758 cites W2060595330 @default.
- W2074276758 cites W2062412252 @default.
- W2074276758 cites W2064100334 @default.
- W2074276758 cites W2067000257 @default.
- W2074276758 cites W2071029835 @default.
- W2074276758 cites W2071185080 @default.
- W2074276758 cites W2077541701 @default.
- W2074276758 cites W2084149528 @default.
- W2074276758 cites W2085069351 @default.
- W2074276758 cites W2085103629 @default.
- W2074276758 cites W2090146642 @default.
- W2074276758 cites W2091691801 @default.
- W2074276758 cites W2091779515 @default.
- W2074276758 cites W2098743337 @default.
- W2074276758 cites W2105007068 @default.
- W2074276758 cites W2116460986 @default.
- W2074276758 cites W2123299765 @default.
- W2074276758 cites W2129859001 @default.
- W2074276758 cites W2132859839 @default.
- W2074276758 cites W2147643233 @default.
- W2074276758 cites W2153450253 @default.
- W2074276758 cites W2160327135 @default.
- W2074276758 cites W2164356347 @default.
- W2074276758 cites W2167164908 @default.
- W2074276758 cites W2171446116 @default.
- W2074276758 cites W2319534054 @default.
- W2074276758 cites W2413819070 @default.
- W2074276758 cites W4230173341 @default.
- W2074276758 cites W4230527064 @default.
- W2074276758 cites W4239885108 @default.
- W2074276758 doi "https://doi.org/10.1016/0031-6865(94)90037-x" @default.
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