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• W2074280330 abstract "Lactoferrin (Lf) is known to have anti-inflammatory activity, but the mechanisms of action by Lf remain to be elucidated. Here, we demonstrated that TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) was down-regulated by Lf in a DNA-binding dependent manner at transcriptional level in endothelial cells. Our results showed that Lf bound to a DNA region in the ICAM-1 promoter in vitro as well as in chromatin context. Lf inhibited binding of NF-κB to a proximal NF-κB site in ICAM-1 promoter. This type of repression represents an additional mechanism for the action of Lf in regulation of gene expression." @default.
• W2074280330 created "2016-06-24" @default.
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• W2074280330 date "2012-01-02" @default.
• W2074280330 modified "2023-09-24" @default.
• W2074280330 title "Human lactoferrin suppresses TNF-α-induced intercellular adhesion molecule-1 expression via competition with NF-κB in endothelial cells" @default.
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• W2074280330 doi "https://doi.org/10.1016/j.febslet.2011.12.011" @default.
• W2074280330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22226679" @default.
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