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• W2074285616 abstract "cRNA encoding the human IsK protein was injected into Xenopus oocytes and the expressed channels were investigated using the two-microelectrode voltage-clamp method. The novel class III antiarrhythmic NE-10064 (1-[[[5-(4-chlorophenyl)-2-furanyl]m methylene]-amino]-3-[4-(4-methyl-1-piperazinyl)-butyl]-2,4-imidazolidinedione dihydrochloride) was tested for its ability to block these channels. The compound displayed potent inhibitory effects with an EC50 of 5.4 μM. The block caused by NE-10064 was use-dependent, i.e. channels had to be activated for the inhibition to occur. Further, the reversal of the inhibition during the wash-out period was use-dependent. Finally, the blockade of human IsK channels by NE-10064 appeared to be voltage-dependent, being more pronounced at depolarized potentials. We conclude that this novel class III antiarrhythmic is a potent inhibitor of human IsK channels and suggest that such effects could be involved in its antiarrhythmic action." @default.
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• W2074285616 date "1994-10-01" @default.
• W2074285616 modified "2023-10-16" @default.
• W2074285616 title "Blockade of human IsK channels expressed in Xenopus oocytes by the novel class III antiarrhythmic NE-10064" @default.
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• W2074285616 doi "https://doi.org/10.1016/0014-2999(94)90632-7" @default.
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