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- W2074294637 abstract "The ability of diltiazem to suppress halothane and halothane-caffeine induced contractures in malignant hyperthermia (MH) susceptible pig muscle, was tested in vitro. Muscle specimens were divided into two groups and tested with a modified halothane-caffeine contracture test. One group acted as the control; the other group was pretreated with diltiazem 20 mumol litre-1. The control muscles developed contractures attributable to halothane and halothane-caffeine, whereas the diltiazem-treated specimens did not. Increases in muscle twitch tension as a result of halothane or halothane-caffeine exposure occurred in treated and untreated specimens, but were significantly delayed in the presence of diltiazem. Muscle exhaustion observed after halothane and halothane-caffeine exposure in the control specimens did not occur in the diltiazem treated muscles." @default.
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- W2074294637 date "1985-07-01" @default.
- W2074294637 modified "2023-09-26" @default.
- W2074294637 title "DILTIAZEM INHIBITS HALOTHANE-INDUCED CONTRACTIONS IN MALIGNANT HYPERTHERMIA-SUSCEPTIBLE MUSCLES IN VITRO" @default.
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- W2074294637 doi "https://doi.org/10.1093/bja/57.10.994" @default.
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