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- W2074302783 endingPage "347" @default.
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- W2074302783 abstract "Adenovirus serotype 5 (Ad5) continues to be regarded as a gene delivery vehicle of high utility for a variety of clinical applications. However, targeting of the virus to alternate, non-native receptors has become a mandate for many gene therapy approaches, as inefficient viral transduction of target tissues has proven detrimental to the utility of Ad5. Thus, various targeting strategies have been endeavored to the end of highly specific cellular transduction, including that of genetic manipulation of the viral capsid. Modification of the tropism-determining fiber protein and other capsid locales has allowed vectorologists to develop vectors that are highly superior to the first-generation adenoviruses employed for gene therapy. Herein, the various genetic targeting strategies for Ad5 are reviewed, and the various schemas in which targeted transduction has been achieved with tropism-modified vectors are outlined." @default.
- W2074302783 created "2016-06-24" @default.
- W2074302783 creator A5012151248 @default.
- W2074302783 creator A5022987623 @default.
- W2074302783 date "2005-09-03" @default.
- W2074302783 modified "2023-09-23" @default.
- W2074302783 title "Genetic Targeting Strategies for Adenovirus" @default.
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- W2074302783 doi "https://doi.org/10.1021/mp050045c" @default.
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