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• W2074303363 endingPage "1715" @default.
• W2074303363 startingPage "1709" @default.
• W2074303363 abstract "Acquired immunodeficiency syndrome (AIDS) results from infection with a human immunodeficiency virus (HIV). The long terminal repeat (LTR) region of HIV proviral DNA contains binding sites for nuclear factor kappa B (NF-kappa B), and this transcriptional activator appears to regulate HIV activation. Recent findings suggest an involvement of reactive oxygen species (ROS) in signal transduction pathways leading to NF-kappa B activation. The present study was based on reports that antioxidants which eliminate ROS should block the activation of NF-kappa B and subsequently HIV transcription, and thus antioxidants can be used as therapeutic agents for AIDS. Incubation of Jurkat T cells (1 x 10(6) cells/ml) with a natural thiol antioxidant, alpha-lipoic acid, prior to the stimulation of cells was found to inhibit NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml). The inhibitory action of alpha-lipoic acid was found to be very potent as only 4 mM was needed for a complete inhibition, whereas 20 mM was required for N-acetylcysteine. These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics." @default.
• W2074303363 created "2016-06-24" @default.
• W2074303363 creator A5028228129 @default.
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• W2074303363 date "1992-12-01" @default.
• W2074303363 modified "2023-09-27" @default.
• W2074303363 title "α-Lipoic acid is a potent inhibitor of NF-κB activation in human T cells" @default.
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• W2074303363 doi "https://doi.org/10.1016/0006-291x(92)90275-p" @default.
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